Ncstn Gene Search Result

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

Genes search result for All species
(View Results for all Objects and Ontologies)

15 records found for search term Ncstn

Refine Term:

Sort By:

Export

RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
631418	Ncstn	nicastrin	ENCODES a protein that exhibits peptidase activity; aspartic endopeptidase activity, intramembrane cleaving (ortholog); ATPase binding (ortholog); INVOLVED IN cerebellum development; protein processing; adult behavior (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; A ... (more) lzheimer's disease pathway; ASSOCIATED WITH alcohol use disorder; chronic myeloid leukemia (ortholog); Familial Acne Inversa 1 (ortholog); FOUND IN early endosome; lysosomal membrane; presynaptic membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil	13	87062827	87078839	Rat	207	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1351739	NCSTN	nicastrin	This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-se ... (more) cretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]	1	160343383	160358949	Human	225	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1551174	Ncstn	nicastrin	Contributes to aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within several processes, including amyloid precursor protein metabolic process; positive regulation of amyloid precursor protein biosynthetic process; and regulation of synaptic plasticity. Located in severa ... (more) l cellular components, including Golgi apparatus; lysosome; and synaptic vesicle. Part of gamma-secretase complex. Is expressed in several structures, including brain and genitourinary system. Used to study chronic myeloid leukemia; schizophrenia; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Jul 2025]	1	171893580	171910356	Mouse	296	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
8838344	Ncstn	nicastrin	ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); ATPase binding (ortholog); endopeptidase activator activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein cata ... (more) bolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); chronic myeloid leukemia (ortholog); Familial Acne Inversa 1 (ortholog); FOUND IN early endosome (ortholog); endoplasmic reticulum (ortholog); gamma-secretase complex (ortholog)	NW_004955468	12111078	12126404	Chinchilla	107	symbol	gene, protein-coding, MODEL [RefSeq]
11732508	NCSTN	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); Alzheimer's disease (ortholog); chronic myeloid leukemia (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)	1	135697592	135713293	Bonobo	105	symbol	gene, protein-coding, MODEL [RefSeq]
12168158	NCSTN	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); Alzheimer's disease (ortholog); chronic myeloid leukemia (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)	38	21878071	21891362	Dog	105	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
12697487	Ncstn	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); Alzheimer's disease (ortholog); chronic myeloid leukemia (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)	NW_004936740	285789	301918	Squirrel	105	symbol	gene, protein-coding, MODEL [RefSeq]
155238052	ncstn						Tropical Clawed Frog		symbol	gene, null
626084134	Ncstn	nicastrin	ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); ATPase binding (ortholog); endopeptidase activator activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein cata ... (more) bolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); chronic myeloid leukemia (ortholog); FOUND IN early endosome (ortholog); endoplasmic reticulum (ortholog); gamma-secretase complex (ortholog)				Black Rat	107	symbol	gene, protein-coding, MODEL [RefSeq]
14003210	NCSTN	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); chronic myeloid leukemia (ortholog); Familial Acne Inversa 1 (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)				Pig	106	symbol	gene, protein-coding, MODEL [RefSeq]
18901958	Ncstn	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); Alzheimer's disease (ortholog); chronic myeloid leukemia (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)				Naked Mole-Rat	105	symbol	gene, protein-coding, MODEL [RefSeq]
18640616	NCSTN	nicastrin	ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN adult behavior (ortholog); amyloid precursor protein biosynthetic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WIT ... (more) H alcohol use disorder (ortholog); chronic myeloid leukemia (ortholog); Familial Acne Inversa 1 (ortholog); FOUND IN early endosome (ortholog); lysosomal membrane (ortholog); presynaptic membrane (ortholog)				Green Monkey	105	symbol	gene, protein-coding, MODEL [RefSeq]
155257169	ncstn.L						African Clawed Frog		symbol	gene, null
155238051	ncstn.S						African Clawed Frog		symbol	gene, null
6481592	NCSTNP1	nicastrin pseudogene 1		21	27492118	27492261	Human		symbol , COSMIC , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]