| 1313360 | NCBP2 | nuclear cap binding protein subunit 2 | The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC prom otes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 196935406 | 196942528 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313361 | Ncbp2 | nuclear cap binding protein subunit 2 | Predicted to enable DNA binding activity and RNA binding activity. Involved in histone mRNA metabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of nuclear cap binding activity complex. Is expressed in genitourinary system. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 31767364 | 31777290 | Mouse | 140 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596188 | Ncbp2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits RNA 7-methylguanosine cap binding; DNA binding (ortholog); mRNA binding (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA cis splicing, via spliceosome (ortholog); mRNA export from nucleus (ortholog); PARTICIPATES IN 5'-end pre-mRNA capping pathw ay; RNA polymerase II transcription elongation pathway; FOUND IN nuclear cap binding complex; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; fipronil | 11 | 82326002 | 82334839 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8870465 | Ncbp2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); mRNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA cis splicing, via spliceosome (ortholog); mRNA export from nucleus (ortholog); PARTICIPATES IN 5'-end pre-mRNA ca pping pathway; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear cap binding complex (ortholog) | NW_004955420 | 12979368 | 12992500 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11955763 | NCBP2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); RNA binding (ortholog); INVOLVED IN histone mRNA metabolic process (inferred); mRNA cis splicing, via spliceosome (inferred); mRNA export from nucleus (inferred); PARTICIPATES IN 5'-end pre-mRNA capping pathway; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear cap binding complex (inferred) | 3 | 194277280 | 194284456 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12578025 | Ncbp2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); RNA binding (ortholog); INVOLVED IN histone mRNA metabolic process (inferred); mRNA cis splicing, via spliceosome (inferred); mRNA export from nucleus (inferred); PARTICIPATES IN 5'-end pre-mRNA capping pathway; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear cap binding complex (inferred) | NW_004936833 | 920683 | 928047 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14109903 | NCBP2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); RNA binding (ortholog); INVOLVED IN histone mRNA metabolic process (inferred); mRNA cis splicing, via spliceosome (inferred); mRNA export from nucleus (inferred); PARTICIPATES IN 5'-end pre-mRNA cap ping pathway; RNA polymerase II transcription elongation pathway; FOUND IN nuclear cap binding complex (ortholog) | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18631191 | NCBP2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); RNA binding (ortholog); INVOLVED IN histone mRNA metabolic process (inferred); mRNA cis splicing, via spliceosome (inferred); mRNA export from nucleus (inferred); PARTICIPATES IN 5'-end pre-mRNA cap ping pathway; RNA polymerase II transcription elongation pathway; FOUND IN nuclear cap binding complex (ortholog) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924632 | Ncbp2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); mRNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA export from nucleus (ortholog); mRNA metabolic process (ortholog); PARTICIPATES IN 5'-end pre-mRNA capping pathwa y; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear cap binding complex (ortholog) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40913220 | NCBP2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); mRNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA export from nucleus (ortholog); mRNA metabolic process (ortholog); PARTICIPATES IN 5'-end pre-mRNA capping pathwa y; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear cap binding complex (ortholog) | 33 | 29911457 | 29943596 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236845 | ncbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626035987 | Ncbp2 | nuclear cap binding protein subunit 2 | ENCODES a protein that exhibits DNA binding (ortholog); mRNA binding (ortholog); RNA 7-methylguanosine cap binding (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA cis splicing, via spliceosome (ortholog); mRNA export from nucleus (ortholog); PARTICIPATES IN 5'-end pre-mRNA ca pping pathway; RNA polymerase II transcription elongation pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear cap binding complex (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251257 | ncbp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481348 | NCBP2-AS1 | NCBP2 antisense RNA 1 | | 3 | 196939877 | 196942534 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 2291780 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 196942674 | 196943543 | Human | 20 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11693595 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog) | 3 | 194284487 | 194285405 | Bonobo | 3 | symbol , old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 124921332 | Ncbp2as2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog) | | | | Squirrel | 3 | symbol , old_gene_name , name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 2292395 | Ncbp2as2 | Ncbp2 antisense 2 (head to head) | Is expressed in nervous system. Orthologous to human NCBP2AS2 (NCBP2 antisense 2 (head to head)). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 31765868 | 31767323 | Mouse | 23 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 18362513 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog) | | | | Green Monkey | 3 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 39131579 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | | | | | Chinchilla | | symbol , name | gene, protein-coding |
| 40907149 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog) | | | | Dog | 3 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 41269461 | Ncbp2as2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog); INTERACTS WITH aristolochic acid A (ortholog); arsane (ortholog); arsenic atom (ortholog) | 11 | 82334926 | 82335691 | Rat | 19 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 152178197 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | | | | | Naked Mole-Rat | | symbol , name | gene, protein-coding |
| 153003053 | NCBP2AS2 | NCBP2 antisense 2 (head to head) | | | | | Pig | | symbol , name | gene, protein-coding |
| 625994327 | Ncbp2as2 | NCBP2 antisense 2 (head to head) | FOUND IN mitochondrion (ortholog) | | | | Black Rat | 3 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1353799 | NCBP2L | nuclear cap binding protein subunit 2 like | Predicted to enable RNA cap binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of nuclear cap binding activity complex. [provided by Alliance of Genome Resources, Jul 2025] | X | 107777733 | 107795829 | Human | 10 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 12333363 | NCBP2L | nuclear cap binding protein subunit 2 like | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); RNA cap binding (inferred); INVOLVED IN mRNA cis splicing, via spliceosome (inferred); mRNA processing (inferred); RNA splicing (inferred); FOUND IN nuclear cap binding complex (inferred); nucleus (inferred) | X | 81314213 | 81315093 | Dog | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13551575 | NCBP2L | nuclear cap binding protein subunit 2 like | | X | 96886920 | 96887445 | Bonobo | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 19833455 | NCBP2L | nuclear cap binding protein subunit 2 like | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); RNA cap binding (inferred); INVOLVED IN mRNA cis splicing, via spliceosome (inferred); mRNA processing (inferred); RNA splicing (inferred); FOUND IN nuclear cap binding complex (inferred); nucleus (inferred) | | | | Pig | 13 | symbol | gene, protein-coding |
| 20865619 | NCBP2L | nuclear cap binding protein subunit 2 like | | | | | Green Monkey | | symbol | gene, protein-coding |
| 40892451 | NCBP2L | nuclear cap binding protein subunit 2 like | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); RNA cap binding (inferred); INVOLVED IN mRNA cis splicing, via spliceosome (inferred); mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); FOUND IN nuclear cap binding complex (inferred); nucl eus (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626181813 | ncbp2as2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626187838 | ncbp2as2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 1350648 | CTIF | cap binding complex dependent translation initiation factor | CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that r ecognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009] | 18 | 48539031 | 48863217 | Human | 74 | description | gene, protein-coding, VALIDATED [RefSeq] |