| 1311957 | Mus81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits 3'-flap endonuclease activity (ortholog); crossover junction DNA endonuclease activity (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); DNA repair (ortholog); double-strand break repair (ortholog); PARTICIPATES IN homolog ous recombination pathway of double-strand break repair; ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOUND IN chromosome, telomeric region (ortholog); endodeoxyribonuclease complex (ortholog); fibrillar center (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A | 1 | 212219793 | 212225214 | Rat | 131 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323679 | MUS81 | MUS81 structure-specific endonuclease subunit | This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017] | 11 | 65859674 | 65867653 | Human | 125 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323680 | Mus81 | MUS81 structure-specific endonuclease subunit | Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA cat abolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nuclear replication fork. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 5532589 | 5538461 | Mouse | 182 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795211 | Mus81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits 3'-flap endonuclease activity (ortholog); crossover junction DNA endonuclease activity (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); DNA repair (ortholog); double-strand break repair (ortholog); ASSOCIATED WITH arteria l tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOUND IN chromosome, telomeric region (ortholog); endodeoxyribonuclease complex (ortholog); fibrillar center (ortholog) | NW_004955422 | 19471552 | 19479121 | Chinchilla | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12010371 | MUS81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOU ND IN chromosome, telomeric region (inferred); endodeoxyribonuclease complex (inferred); fibrillar center (inferred) | 11 | 61220699 | 61226747 | Bonobo | 60 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12344905 | MUS81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOU ND IN chromosome, telomeric region (inferred); endodeoxyribonuclease complex (inferred); fibrillar center (inferred) | 18 | 51396980 | 51404563 | Dog | 61 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12627246 | Mus81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOU ND IN chromosome, telomeric region (inferred); endodeoxyribonuclease complex (inferred); fibrillar center (inferred) | NW_004936599 | 3670759 | 3677375 | Squirrel | 60 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18527958 | MUS81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); osteoblast proliferation (ortholog); resolution of mitotic recombination intermediates (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOUND IN chromosome, telomeric region (ortholog); fibrillar center (ortholog); nuclear replication fork (ortholog) | | | | Green Monkey | 51 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13904223 | MUS81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOU ND IN chromosome, telomeric region (inferred); endodeoxyribonuclease complex (inferred); fibrillar center (inferred) | | | | Pig | 60 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626164367 | Mus81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits 3'-flap endonuclease activity (ortholog); crossover junction DNA endonuclease activity (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); DNA repair (ortholog); double-strand break repair (ortholog); ASSOCIATED WITH arteria l tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOUND IN chromosome, telomeric region (ortholog); endodeoxyribonuclease complex (ortholog); fibrillar center (ortholog) | | | | Black Rat | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14380909 | MUS81 | | | | | | Yeast | | symbol | gene, null |
| 155248919 | mus81 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18927895 | Mus81 | MUS81 structure-specific endonuclease subunit | ENCODES a protein that exhibits DNA endonuclease activity (ortholog); INVOLVED IN DNA catabolic process (ortholog); osteoblast proliferation (ortholog); resolution of mitotic recombination intermediates (ortholog); ASSOCIATED WITH arterial tortuosity syndrome (ortholog); Marfan syndrome (ortholog); pulmonary emphysema (ortholog); FOUND IN chromosome, telomeric region (ortholog); fibrillar center (ortholog); nuclear replication fork (ortholog) | | | | Naked Mole-Rat | 52 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14380911 | mus81 | | | | | | Fly | | symbol | gene, null |
| 155248920 | mus81.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 18583783 | LOC103243152 | crossover junction endonuclease MUS81 | ENCODES a protein that exhibits 3'-flap endonuclease activity (inferred); crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); INVOLVED IN DNA catabolic process (inferred); DNA damage response (inferred); DNA recombination (inferred); FOUND IN endodeoxyribonuclease comple x (inferred); Holliday junction resolvase complex (inferred); nucleolus (inferred) | | | | Green Monkey | 31 | name | gene, protein-coding, MODEL [RefSeq] |
| 12082489 | LOC100683112 | crossover junction endonuclease MUS81-like | | 38 | 16052540 | 16053754 | Dog | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1344240 | EME2 | essential meiotic structure-specific endonuclease subunit 2 | EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008] | 16 | 1772810 | 1781702 | Human | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |