| 620797 | Mtnr1a | melatonin receptor 1A | ENCODES a protein that exhibits hormone binding (ortholog); melatonin receptor activity (ortholog); INVOLVED IN camera-type eye development; circadian rhythm; negative regulation of insulin secretion; ASSOCIATED WITH type 2 diabetes mellitus; amyotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN neuronal cell body; plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 16 | 53876964 | 53896421 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734169 | Mtnr1a | melatonin receptor 1A | Predicted to enable hormone binding activity and melatonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and negative regulation of insulin secretion. Predicted to act upstream of or within circadian rhythm. Predicted to be l ocated in neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; liver and biliary system; and reproductive system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 45522144 | 45542270 | Mouse | 133 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1352571 | MTNR1A | melatonin receptor 1A | This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008] | 4 | 186533655 | 186555567 | Human | 109 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9056968 | Mtnr1a | melatonin receptor 1A | ENCODES a protein that exhibits hormone binding (ortholog); melatonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); camera-type eye development (ortholog); circadian rhythm (ortholog); ASSOCIATED WITH amyotrophic later al sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog); plasma membrane (ortholog); receptor complex (ortholog) | NW_004955403 | 22636212 | 22658566 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668388 | MTNR1A | melatonin receptor 1A | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); hormone binding (inferred); melatonin receptor activity (inferred); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); negative regulation of insulin secretion (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog) | 4 | 178693869 | 178720351 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12188932 | MTNR1A | melatonin receptor 1A | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); hormone binding (inferred); melatonin receptor activity (inferred); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); negative regulation of insulin secretion (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog) | 16 | 44258239 | 44286761 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12472939 | Mtnr1a | melatonin receptor 1A | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); hormone binding (inferred); melatonin receptor activity (inferred); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); negative regulation of insulin secretion (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog) | NW_004936554 | 3013106 | 3047171 | Squirrel | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405864341 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625885070 | Mtnr1a | melatonin receptor 1A | ENCODES a protein that exhibits hormone binding (ortholog); melatonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); camera-type eye development (ortholog); circadian rhythm (ortholog); ASSOCIATED WITH amyotrophic later al sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog); plasma membrane (ortholog); receptor complex (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14198278 | MTNR1A | melatonin receptor 1A | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); hormone binding (inferred); melatonin receptor activity (inferred); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); negative regulation of insulin secretion (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog) | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18795781 | MTNR1A | melatonin receptor 1A | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); hormone binding (inferred); melatonin receptor activity (inferred); INVOLVED IN camera-type eye development (ortholog); circadian rhythm (ortholog); negative regulation of insulin secretion (ortholog); ASSOCIATED WITH am yotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405858779 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863494 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405865568 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857387 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18925412 | Mtnr1a | melatonin receptor 1A | ENCODES a protein that exhibits hormone binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); camera-type eye development (ortholog); circadian rhythm (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); Huntington's disease (ortholog); FOUND IN neuronal cell body (ortholog); receptor complex (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857973 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405859174 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863872 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405860168 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405864002 | mtnr1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179956 | mtnr1al.S | | | | | | African Clawed Frog | | symbol | gene, null |
