| 1348876 | MED24 | mediator complex subunit 24 | This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene exp ression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 17 | 40019104 | 40054408 | Human | 91 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1564565 | Med24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity; protein-containing complex binding; transcription coactivator activity; INVOLVED IN protein ubiquitination; positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription initiation by RNA polyme rase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex; core mediator complex (ortholog); mediator complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A | 10 | 84160866 | 84198607 | Rat | 90 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1620081 | Med24 | mediator complex subunit 24 | This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene exp ression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] | 11 | 98595423 | 98620245 | Mouse | 117 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9053635 | Med24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); nuclear thyroid hormone receptor binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription initiatio n by RNA polymerase II (ortholog); protein ubiquitination (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN core mediator complex (ortholog); mediator complex (ortholog); nucleus (ortholog) | NW_004955451 | 14690721 | 14712038 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11880918 | MED24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); protein-containing complex binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); stem cell population maintenance (ortholog); transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | 17 | 17234660 | 17269794 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12179342 | MED24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); protein-containing complex binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); stem cell population maintenance (ortholog); transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | 9 | 22500937 | 22528262 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12504437 | Med24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); protein-containing complex binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); stem cell population maintenance (ortholog); transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | NW_004936490 | 15146598 | 15181449 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920454 | Med24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); nuclear thyroid hormone receptor binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); protein ubiquitination (ortholog); stem cell p opulation maintenance (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN core mediator complex (ortholog); ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250635 | med24 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13922446 | MED24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); protein-containing complex binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); stem cell population maintenance (ortholog); transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14388175 | MED24 | | | | | | Fly | | symbol | gene, null |
| 625931645 | Med24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); nuclear thyroid hormone receptor binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription initiatio n by RNA polymerase II (ortholog); protein ubiquitination (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN core mediator complex (ortholog); mediator complex (ortholog); nucleus (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18427974 | MED24 | mediator complex subunit 24 | ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); protein-containing complex binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); stem cell population maintenance (ortholog); transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH Dwarfism (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252315 | med24.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1606332 | MED22 | mediator complex subunit 22 | This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isof orms have been observed. [provided by RefSeq, Jul 2013] | 9 | 133338312 | 133348131 | Human | 68 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |