| 1306628 | Lztfl1 | leucine zipper transcription factor-like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN flagellated sperm motility (ortholog); negative regulation of protein localization to ciliary membrane (ortholog); negative regulation of protein localization to cilium (o rtholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 17 (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene; bisphenol A | 8 | 132222339 | 132237757 | Rat | 112 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315352 | LZTFL1 | leucine zipper transcription factor like 1 | This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020] | 3 | 45823316 | 45915724 | Human | 248 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315353 | Lztfl1 | leucine zipper transcription factor-like 1 | Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility and spermatogenesis. Located in cilium; cytoplasm; and manchette. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Bied l syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 123523469 | 123546690 | Mouse | 165 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8792901 | Lztfl1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN flagellated sperm motility (ortholog); negative regulation of protein localization to ciliary membrane (ortholog); negative regulation of protein localization to cilium (o rtholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 17 (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955420 | 26130432 | 26145516 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11841716 | LZTFL1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cytoplasm (ortholog) | 3 | 45733361 | 45823810 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12176968 | LZTFL1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cilium (inferred); cytoplasm (inferred); cytosol (inferred) | 20 | 42651762 | 42666426 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12674041 | Lztfl1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936695 | 106216 | 118408 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14193441 | LZTFL1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cilium (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625882298 | Lztfl1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN flagellated sperm motility (ortholog); negative regulation of protein localization to ciliary membrane (ortholog); negative regulation of protein localization to cilium (o rtholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 17 (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249779 | lztfl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18910859 | Lztfl1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18504974 | LZTFL1 | leucine zipper transcription factor like 1 | ENCODES a protein that exhibits identical protein binding (inferred); protein-containing complex binding (inferred); INVOLVED IN flagellated sperm motility (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndr ome 17 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253981 | lztfl1.L | | | | | | African Clawed Frog | | symbol | gene, null |