| 620563 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding; phospholipid binding; lysophosphatidic acid binding (ortholog); INVOLVED IN cellular response to 1-oleoyl-sn-glycerol 3-phosphate; cellular response to oxygen levels; cerebellum development; PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH abnormal craniofacial development; decreased body size; ASSOCIATED WITH hepatocellular carcinoma; Retina Reperfusion Injury; transient cerebral ischemia; FOUND IN dendritic shaft; dendritic spine; GABA-ergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 78024139 | 78147071 | Rat | 272 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731581 | LPAR1 | lysophosphatidic acid receptor 1 | The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020] | 9 | 110873263 | 111038998 | Human | 257 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731582 | Lpar1 | lysophosphatidic acid receptor 1 | Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of stress fiber assem bly. Acts upstream of or within bleb assembly. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 58435252 | 58554601 | Mouse | 318 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8918126 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); lysophosphatidic acid binding (ortholog); lysophosphatidic acid receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); bleb assembly (ortholog); cell c hemotaxis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (ortholog); dendritic shaft (ortholog); dendritic spine (ortholog) | NW_004955419 | 16190109 | 16324702 | Chinchilla | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11761716 | LPAR1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); phospholipid binding (ortholog); INVOLVED IN bleb assembly (ortholog); cellular response to 1-oleoyl-sn-glycerol 3-phosphate (ortholog); cellular response to oxygen levels (ortholog); PARTICIPATES IN G protein mediated signa ling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); GABA-ergic synapse (ortholog) | 9 | 82013960 | 82179227 | Bonobo | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12259450 | LPAR1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); phospholipid binding (ortholog); INVOLVED IN bleb assembly (ortholog); cellular response to 1-oleoyl-sn-glycerol 3-phosphate (ortholog); cellular response to oxygen levels (ortholog); PARTICIPATES IN G protein mediated signa ling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); GABA-ergic synapse (ortholog) | 11 | 65690806 | 65822166 | Dog | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12588418 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); phospholipid binding (ortholog); INVOLVED IN bleb assembly (ortholog); cellular response to 1-oleoyl-sn-glycerol 3-phosphate (ortholog); cellular response to oxygen levels (ortholog); PARTICIPATES IN G protein mediated signa ling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); GABA-ergic synapse (ortholog) | NW_004936559 | 2187791 | 2331587 | Squirrel | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241080 | lpar1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18574447 | LPAR1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); phospholipid binding (ortholog); INVOLVED IN bleb assembly (ortholog); cellular response to 1-oleoyl-sn-glycerol 3-phosphate (ortholog); cellular response to oxygen levels (ortholog); PARTICIPATES IN G protein mediated signa ling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); GABA-ergic synapse (ortholog) | | | | Green Monkey | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14052850 | LPAR1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); lysophosphatidic acid binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); bleb assembly (ortholog); cell chemotaxis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); endocytic vesicle (ortholog) | | | | Pig | 78 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626129130 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); lysophosphatidic acid binding (ortholog); lysophosphatidic acid receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); bleb assembly (ortholog); cell c hemotaxis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (ortholog); dendritic shaft (ortholog); dendritic spine (ortholog) | | | | Black Rat | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903089 | Lpar1 | lysophosphatidic acid receptor 1 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); lysophosphatidic acid binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); bleb assembly (ortholog); cell chemotaxis (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN dendritic shaft (ortholog); dendritic spine (ortholog); endocytic vesicle (ortholog) | | | | Naked Mole-Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252963 | lpar1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241079 | lpar1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 126848739 | Lpar1m1Hubr | lysophosphatidic acid receptor 1; ENU induced mutant 1, Hubr | ASSOCIATED WITH abnormal craniofacial development; decreased body size | | | | Rat | 2 | symbol , description | gene, allele |