| 1311393 | Lman2l | lectin, mannose-binding 2-like | ENCODES a protein that exhibits carbohydrate binding (inferred); metal ion binding (inferred); INVOLVED IN protein transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipola r disorder (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ortholog); INTERACTS WITH bisphenol A; leflunomide; thioacetamide | 9 | 46157596 | 46181151 | Rat | 79 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322831 | LMAN2L | lectin, mannose binding 2 like | This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, wh ich cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016] | 2 | 96705929 | 96740064 | Human | 97 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322832 | Lman2l | lectin, mannose-binding 2-like | Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 69 and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 36458274 | 36484352 | Mouse | 87 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8895838 | Lman2l | lectin, mannose binding 2 like | INVOLVED IN protein transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ort holog) | NW_004955470 | 4080723 | 4100662 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11863131 | LMAN2L | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); D-mannose binding (inferred); metal ion binding (inferred); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (inferred); protein transport (inferred); ASSOCIATED WITH autosomal dominant intellectual developmental d isorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN COPII-coated ER to Golgi transport vesicle (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred) | 2A | 102573894 | 102608066 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12223751 | LMAN2L | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); metal ion binding (inferred); INVOLVED IN protein transport (inferred); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipola r disorder (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred) | 10 | 45215871 | 45245961 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12645228 | Lman2l | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); D-mannose binding (inferred); metal ion binding (inferred); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (inferred); protein transport (inferred); ASSOCIATED WITH autosomal dominant intellectual developmental d isorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN COPII-coated ER to Golgi transport vesicle (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred) | NW_004936744 | 665893 | 691335 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910043 | Lman2l | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); D-mannose binding (inferred); metal ion binding (inferred); INVOLVED IN protein transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18754121 | LMAN2L | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); D-mannose binding (inferred); metal ion binding (inferred); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (inferred); protein transport (inferred); ASSOCIATED WITH autosomal dominant intellectual developmental d isorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN COPII-coated ER to Golgi transport vesicle (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236003 | lman2l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14043072 | LMAN2L | lectin, mannose binding 2 like | ENCODES a protein that exhibits carbohydrate binding (inferred); metal ion binding (inferred); INVOLVED IN protein transport (inferred); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipola r disorder (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum membrane (inferred); Golgi apparatus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 25 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626144563 | Lman2l | lectin, mannose binding 2 like | INVOLVED IN protein transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 69 (ortholog); autosomal recessive intellectual developmental disorder 52 (ortholog); bipolar disorder (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); Golgi apparatus (ort holog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236002 | lman2l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258801 | lman2l.S | | | | | | African Clawed Frog | | symbol | gene, null |