| 1354394 | KRT10 | keratin 10 | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, com pose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008] | 17 | 40818117 | 40822614 | Human | 268 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1359092 | Krt10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cornification (ortholog); epidermis development (ortholog); PARTICIPA TES IN Staphylococcus aureus infection pathway; ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosis 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); keratin filament (ortholog); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17alpha-ethynylestradiol | 10 | 84834865 | 84839160 | Rat | 218 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1550484 | Krt10 | keratin 10 | Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within several processes, including cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in cytoplasm and keratin filame nt. Is active in cornified envelope. Is expressed in several structures, including alimentary system; lower urinary tract; penis; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis and epidermolytic hyperkeratosis 2. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 99276080 | 99288631 | Mouse | 262 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8974264 | Krt10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cornification (ortholog); epidermis development (ortholog); ASSOCIATE D WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosis 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); keratin filament (ortholog) | NW_004955451 | 15269861 | 15274351 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11819823 | KRT10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); epithelial cell differentiation (ortholog); ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosi s 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog) | 17 | 16461624 | 16466136 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12427596 | KRT10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); epithelial cell differentiation (ortholog); ASSOCIATED WITH epidermolytic hyperkeratosis ; Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosis 1 (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog) | 9 | 21863715 | 21868587 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12649133 | Krt10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); epithelial cell differentiation (ortholog); ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosi s 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog) | NW_004936490 | 15783636 | 15788605 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18554273 | KRT10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); epithelial cell differentiation (ortholog); ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosi s 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917575 | Krt10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cornification (ortholog); epidermis development (ortholog); ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); A nnular Epidermolytic Ichthyosis 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14088591 | KRT10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); epidermis development (ortholog); epithelial cell differentiation (ortholog); ASSOCIATED WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosi s 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625839377 | Krt10 | keratin 10 | ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); protein heterodimerization activity (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cornification (ortholog); epidermis development (ortholog); ASSOCIATE D WITH Annular Epidermolytic Ichthyosis (ortholog); Annular Epidermolytic Ichthyosis 1 (ortholog); Arsenic Poisoning (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); keratin filament (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1603177 | KRT10-AS1 | KRT10 antisense RNA 1 | Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 40819145 | 40836274 | Human | 23 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 11922078 | LOC100993221 | transmembrane protein 99 (putative) | | 17 | 16447929 | 16465165 | Bonobo | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18694833 | LOC103243487 | transmembrane protein 99 (putative) | | | | | Green Monkey | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1346930 | KRT1 | keratin 1 | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] | 12 | 52674736 | 52680407 | Human | 401 | description | gene, protein-coding, REVIEWED [RefSeq] |