| 1351288 | IL16 | interleukin 16 | The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] | 15 | 81182712 | 81314058 | Human | 189 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557964 | Il16 | interleukin 16 | Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracel lular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 83292027 | 83395479 | Mouse | 194 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1583872 | Il16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (ortholog); cytokine activity (ortholog); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); positive regulation of inflammatory response (ortholog); ASSOCIATED WITH borna disease; Brain Injuries; Experimenta l Autoimmune Encephalomyelitis; FOUND IN cytosol (ortholog); nuclear speck (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | 1 | 147026852 | 147127177 | Rat | 189 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8815291 | Il16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (ortholog); cytokine activity (ortholog); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); positive regulation of inflammatory response (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortho log); borna disease (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog) | NW_004955416 | 11876317 | 11987548 | Chinchilla | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12015803 | IL16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); borna diseas e (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | 15 | 60181827 | 60299406 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12241980 | IL16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); ASSOCIATED WITH allergic disease (ortholog); borna disease (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | 3 | 56473485 | 56575504 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12485783 | Il16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); borna diseas e (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | NW_004936483 | 19417580 | 19512654 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14074423 | IL16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); borna diseas e (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | | | | Pig | 55 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18923115 | Il16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); positive regulation of inflammatory response (ortholog); ASSOCIATED WITH all ergic disease (ortholog); asthma (ortholog); borna disease (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18452421 | IL16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (inferred); cytokine activity (inferred); signaling receptor binding (inferred); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); ASSOCIATED WITH allergic disease (ortholog); borna disease (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285689535 | il16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626017843 | Il16 | interleukin 16 | ENCODES a protein that exhibits CD4 receptor binding (ortholog); cytokine activity (ortholog); INVOLVED IN induction of positive chemotaxis (ortholog); leukocyte chemotaxis (ortholog); positive regulation of inflammatory response (ortholog); ASSOCIATED WITH allergic disease (ortholog); asthma (ortho log); borna disease (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog) | | | | Black Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285469683 | il16.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858538 | il16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857349 | il16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171907 | il16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862340 | il16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861481 | il16.S | | | | | | African Clawed Frog | | symbol | gene, null |