| 1317828 | IDI2 | isopentenyl-diphosphate delta isomerase 2 | The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016] | 10 | 1018910 | 1025859 | Human | 49 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321674 | Idi2 | isopentenyl-diphosphate delta isomerase 2 | Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Acts upstream of or within negative regulation of cholesterol biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Orthologous to human IDI2 (isope ntenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 9002899 | 9010981 | Mouse | 44 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1559783 | Idi2 | isopentenyl-diphosphate delta isomerase 2 | ENCODES a protein that exhibits isopentenyl-diphosphate delta-isomerase activity (ortholog); INVOLVED IN isopentenyl diphosphate metabolic process (ortholog); isoprenoid biosynthetic process (ortholog); negative regulation of cholesterol biosynthetic process (ortholog); FOUND IN peroxisome (ortholog ); INTERACTS WITH bisphenol A; indole-3-methanol; trichloroethene | 17 | 66022731 | 66026333 | Rat | 37 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11935288 | IDI2 | isopentenyl-diphosphate delta isomerase 2 | ENCODES a protein that exhibits intramolecular oxidoreductase activity (inferred); isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); INVOLVED IN isopentenyl diphosphate metabolic process (ortholog); negative regulation of cholesterol biosynthetic process (or tholog); FOUND IN cytoplasm (inferred); peroxisome (inferred) | 10 | 1056280 | 1062070 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12503160 | Idi2 | isopentenyl-diphosphate delta isomerase 2 | ENCODES a protein that exhibits isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); metal ion binding (inferred); INVOLVED IN isopentenyl diphosphate metabolic process (ortholog); negative regulation of cholesterol biosynthetic process (ortholog); FOUND IN cyt oplasm (inferred); peroxisome (inferred) | NW_004936484 | 13086928 | 13092291 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626069662 | Idi2 | isopentenyl-diphosphate delta isomerase 2 | ENCODES a protein that exhibits isopentenyl-diphosphate delta-isomerase activity (ortholog); INVOLVED IN isopentenyl diphosphate metabolic process (ortholog); isoprenoid biosynthetic process (ortholog); negative regulation of cholesterol biosynthetic process (ortholog); FOUND IN peroxisome (ortholog ) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1353147 | IDI2-AS1 | IDI2 antisense RNA 1 | INTERACTS WITH (-)-epigallocatechin 3-gallate; aflatoxin B1; Aflatoxin B2 alpha | 10 | 1022637 | 1044201 | Human | 20 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 9352023 | Idi2-ps1 | isopentenyl-diphosphate delta isomerase 2, pseudogene 1 | ENCODES a protein that exhibits isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); INVOLVED IN cholesterol biosynthetic process (inferred); cholesterol metabolic process (inferred); isoprenoid biosynthetic process (inferred); FOUND IN peroxisome (inferred) | | | | Rat | 11 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 18922061 | LOC101702441 | isopentenyl-diphosphate delta-isomerase 2 | ENCODES a protein that exhibits isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); metal ion binding (inferred); INVOLVED IN cholesterol biosynthetic process (inferred); cholesterol metabolic process (inferred); isopentenyl diphosphate biosynthetic process (i nferred); FOUND IN cytoplasm (inferred); peroxisome (inferred) | | | | Naked Mole-Rat | 16 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11916556 | LOC100976533 | uncharacterized protein IDI2-AS1-like | | 10 | 1075140 | 1082050 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 2295617 | Idi2l | isopentenyl-diphosphate delta isomerase 2 like | Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2025] | 13 | 8991022 | 8998279 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1564347 | Idi2l2 | isopentenyl-diphosphate delta isomerase 2 like 2 | ENCODES a protein that exhibits isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); INVOLVED IN cholesterol biosynthetic process (inferred); cholesterol metabolic process (inferred); dimethylallyl diphosphate biosynthetic process (inferred); FOUND IN peroxisom e (inferred); INTERACTS WITH vinclozolin | 17 | 66064199 | 66077329 | Rat | 16 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1564999 | Idi2l3 | isopentenyl-diphosphate delta isomerase 2 like 3 | ENCODES a protein that exhibits isomerase activity (inferred); isopentenyl-diphosphate delta-isomerase activity (inferred); INVOLVED IN cholesterol biosynthetic process (inferred); cholesterol metabolic process (inferred); dimethylallyl diphosphate biosynthetic process (inferred); PARTICIPATES IN te rpenoid biosynthetic pathway; FOUND IN peroxisome (inferred); INTERACTS WITH acrylamide; allopurinol; bisphenol A | 17 | 66243932 | 66258028 | Rat | 23 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |