| 1303334 | Hyal3 | hyaluronidase 3 | ENCODES a protein that exhibits hyaluronoglucuronidase activity (ortholog); hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (orth olog); PARTICIPATES IN glycosaminoglycan degradation pathway; FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A | 8 | 117133028 | 117138663 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1344724 | HYAL3 | hyaluronidase 3 | This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell prolifer ation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011] | 3 | 50292832 | 50299405 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1620668 | Hyal3 | hyaluronoglucosaminidase 3 | Enables hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; negative regulation of ovarian follicle development; and ovarian follicle atresia. Located in cytoplasmic vesicle; endoplasmic reticulum; and sperm midpiece. Is expressed in several str uctures, including cardiovascular system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human HYAL3 (hyaluronidase 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 107458495 | 107464558 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9040769 | Hyal3 | hyaluronidase 3 | ENCODES a protein that exhibits hyaluronoglucuronidase activity (ortholog); hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (orth olog); FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); cytoplasmic vesicle (ortholog) | NW_004955532 | 2107019 | 2112356 | Chinchilla | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11837744 | HYAL3 | hyaluronidase 3 | ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); cartilage development (inferred); cellular response to interleukin-1 (inferred); FOUND IN acrosomal membrane (inferred); acrosomal vesicle (inferred); cytoplasmic vesicle (inferred) | 3 | 50221428 | 50228062 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12267755 | HYAL3 | hyaluronidase 3 | ENCODES a protein that exhibits hyaluronoglucuronidase activity (ortholog); hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (orth olog); FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH masitinib | 20 | 39041940 | 39047388 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12721517 | Hyal3 | hyaluronidase 3 | ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); cartilage development (inferred); cellular response to interleukin-1 (inferred); FOUND IN acrosomal membrane (inferred); acrosomal vesicle (inferred); cytoplasmic vesicle (inferred) | NW_004936529 | 1831639 | 1837314 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625945140 | Hyal3 | hyaluronidase 3 | ENCODES a protein that exhibits hyaluronoglucuronidase activity (ortholog); hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (orth olog); FOUND IN acrosomal membrane (ortholog); acrosomal vesicle (ortholog); cytoplasmic vesicle (ortholog) | | | | Black Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910383 | Hyal3 | hyaluronidase 3 | ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); cartilage development (inferred); cellular response to interleukin-1 (inferred); FOUND IN acrosomal membrane (inferred); acrosomal vesicle (inferred); cytoplasmic vesicle (inferred) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13867191 | HYAL3 | hyaluronidase 3 | ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN hyaluronan catabolic process (ortholog); negative regulation of ovarian follicle development (ortholog); ovarian follicle atresia (ortholog); FOUND IN acrosomal membrane (or tholog); acrosomal vesicle (ortholog); cytoplasmic vesicle (ortholog) | | | | Pig | 55 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18702407 | HYAL3 | hyaluronidase 3 | ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); cartilage development (inferred); cellular response to interleukin-1 (inferred); FOUND IN acrosomal membrane (inferred); acrosomal vesicle (inferred); cytoplasmic vesicle (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1347791 | SPAM1 | sperm adhesion molecule 1 | Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] | 7 | 123925241 | 123971414 | Human | 36 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
