| 1351931 | HOXC4 | homeobox C4 | This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are locat ed on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008] | 12 | 54016888 | 54056030 | Human | 91 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] | | 1558279 | Hoxc4 | homeobox C4 | Enables HMG box domain binding activity. Acts upstream of or within anterior/posterior pattern specification; cartilage development; and embryonic organ morphogenesis. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; nervous s ystem; skin; and urinary system. Orthologous to human HOXC4 (homeobox C4). [provided by Alliance of Genome Resources, Apr 2025] | 15 | 102926531 | 102945281 | Mouse | 118 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] | | 1586210 | Hoxc4 | homeo box C4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); HMG box domain binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glial cell derived neurotrophic f actor; positive regulation of male germ-line stem cell asymmetric division; anterior/posterior pattern specification (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride | 7 | 136049059 | 136051601 | Rat | 91 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] | | 8887608 | Hoxc4 | homeobox C4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); HMG box domain binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); c artilage development (ortholog); cellular response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955458 | 1251601 | 1313291 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] | | 11704541 | HOXC4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 12 | 34699357 | 34702368 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] | | 12405633 | HOXC4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 27 | 1209510 | 1246873 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] | | 12461550 | Hoxc4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936512 | 11238905 | 11277531 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] | | 18922022 | Hoxc4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] | | 155259097 | hoxc4 | | | | | | Tropical Clawed Frog | | symbol | gene, null | | 13912512 | HOXC4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] | | 18758543 | HOXC4 | homeobox C4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); cartilage development (ortholog); cellul ar response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] | | 625913111 | Hoxc4 | homeobox C4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); HMG box domain binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); c artilage development (ortholog); cellular response to glial cell derived neurotrophic factor (ortholog); ASSOCIATED WITH esophageal atresia (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] | | 405862129 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 626187733 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 405859971 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 405859231 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 405864392 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 626188223 | hoxc4.L | | | | | | African Clawed Frog | | symbol | gene, null | | 405863151 | hoxc4.S | | | | | | African Clawed Frog | | symbol | gene, null | | 626468173 | hoxc4.S | | | | | | African Clawed Frog | | symbol | gene, null | | 405857186 | hoxc4.S | | | | | | African Clawed Frog | | symbol | gene, null | | 405864827 | hoxc4.S | | | | | | African Clawed Frog | | symbol | gene, null | | 405861192 | hoxc4.S | | | | | | African Clawed Frog | | symbol | gene, null | | 1344989 | HOXC5 | homeobox C5 | This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are locat ed on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008] | 12 | 54016888 | 54035361 | Human | 66 | description | gene, protein-coding, REVIEWED [RefSeq] | | 1348360 | HOXC6 | homeobox C6 | This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on diffe rent chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008] | 12 | 54016888 | 54030823 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] | |
