| 1304928 | Hmx1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ort holog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 14 | 79585840 | 79589626 | Rat | 75 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] | | 1312652 | HMX1 | H6 family homeobox 1 | This gene encodes a transcription factor that belongs to the H6 family of homeobox proteins. This protein can bind a 5'-CAAG-3' core DNA sequence, and it is involved in the development of craniofacial structures. Mutations in this gene cause oculoauricular syndrome, a disorder of the eye and externa l ear. [provided by RefSeq, Oct 2009] | 4 | 8846076 | 8871839 | Human | 127 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] | | 1312653 | Hmx1 | H6 homeobox 1 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in sev eral structures, including branchial arch; cranial ganglion; eye; genitourinary system; and peripheral nervous system. Used to study oculoauricular syndrome. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Orthologous to human HMX1 (H6 family homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 35546124 | 35557629 | Mouse | 88 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] | | 8763435 | Hmx1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ort holog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog) | NW_004955514 | 2441234 | 2442478 | Chinchilla | 15 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 12430473 | HMX1 | H6 family homeobox 1 | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Craniofac ial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 3 | 60503149 | 60506799 | Dog | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 12496053 | Hmx1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DN A-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | NW_004936477 | 19958786 | 19962657 | Squirrel | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 18928753 | Hmx1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 14377278 | HMX1 | | | | | | Yeast | | symbol | gene, null | | 626001565 | Hmx1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ort holog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog) | | | | Black Rat | 15 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 155251956 | hmx1 | | | | | | Tropical Clawed Frog | | symbol | gene, null | | 14157159 | HMX1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DN A-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 18530966 | HMX1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DN A-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 152178100 | HMX1 | H6 family homeobox 1 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding | | 32731885 | HMX1 | H6 family homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ort holog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog) | | | | Bonobo | 15 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] | | 626176404 | hmx1.L | | | | | | African Clawed Frog | | symbol | gene, null | | 626172731 | hmx1.L | | | | | | African Clawed Frog | | symbol | gene, null | | 626186322 | hmx1.L | | | | | | African Clawed Frog | | symbol | gene, null | | 628359584 | hmx1.S | | | | | | African Clawed Frog | | symbol | gene, null | | 628359569 | hmx1.S | | | | | | African Clawed Frog | | symbol | gene, null | | 626469792 | HMX1-AS1 | HMX1 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna | | 16561710 | AC116612.1 | novel transcript, sense intronic to HMX1 | | | | | Human | | name | gene, lncrna | |
