| 1352812 | HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | Enables hydroxymethylglutaryl-CoA lyase activity. Involved in ketone body biosynthetic process. Located in several cellular components, including cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 55434373 | 55678919 | Human | 61 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1565090 | Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits hydroxymethylglutaryl-CoA lyase activity (ortholog); INVOLVED IN ketone body biosynthetic process (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; ketamine | 8 | 85637708 | 85799759 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1616589 | Hmgcll1 | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 | Predicted to enable hydroxymethylglutaryl-CoA lyase activity and metal ion binding activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Predicted to be located in membrane and perinuclear region of cytoplasm. Predicted to be active in cytosol and en doplasmic reticulum. Is expressed in several structures, including blastocyst; extraembryonic component; limb; nervous system; and respiratory system. Orthologous to human HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 75921983 | 76043632 | Mouse | 68 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9018002 | Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits hydroxymethylglutaryl-CoA lyase activity (ortholog); INVOLVED IN ketone body biosynthetic process (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | NW_004955411 | 760660 | 881415 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12046071 | HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); L-leucine catabolic process (inferred); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred ); membrane (inferred) | 6 | 54979984 | 55125291 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12310120 | HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred); membrane (inferred) | 12 | 22748798 | 22953849 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12537660 | Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); L-leucine catabolic process (inferred); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred ); membrane (inferred) | NW_004936476 | 5600154 | 5735721 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18664937 | HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); L-leucine catabolic process (inferred); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred ); membrane (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931488 | Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); L-leucine catabolic process (inferred); FOUND IN membrane (ortholog); perinuclear region of cytoplas m (ortholog) | | | | Naked Mole-Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256337 | hmgcll1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626054353 | Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits hydroxymethylglutaryl-CoA lyase activity (ortholog); INVOLVED IN ketone body biosynthetic process (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog) | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14157170 | HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase like 1 | ENCODES a protein that exhibits catalytic activity (inferred); hydroxymethylglutaryl-CoA lyase activity (inferred); lyase activity (inferred); INVOLVED IN ketone body biosynthetic process (inferred); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred); membrane (inferred) | | | | Pig | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251213 | hmgcll1.L | | | | | | African Clawed Frog | | symbol | gene, null |
