| 621339 | Hes3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription; hindbrain morphogenesis (ortholog); i n utero embryonic development (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; all-trans-retinoic acid | 5 | 168076337 | 168082270 | Rat | 63 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733887 | Hes3 | hes family bHLH transcription factor 3 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of timing of neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 152369707 | 152376133 | Mouse | 85 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604433 | HES3 | hes family bHLH transcription factor 3 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of neurogenesis. Predicted to act upstream of or within several processes, including nervous system development; regulation of timing of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 6244179 | 6245578 | Human | 61 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8768987 | Hes3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog) | NW_004955486 | 6272757 | 6273721 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11706750 | HES3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog); FOUND IN nucleus (inferred) | 1 | 5008155 | 5012868 | Bonobo | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12280528 | HES3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain development (ortholog); FOUND IN nucleus (inferred) | 5 | 60134351 | 60136924 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12568609 | Hes3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog); FOUND IN nucleus (inferred) | NW_004936623 | 1096519 | 1098175 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18548924 | HES3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286872013 | hes3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626056633 | Hes3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903332 | Hes3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain d evelopment (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865647 | HES3 | hes family bHLH transcription factor 3 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 14209993 | HES3 | hes family bHLH transcription factor 3 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN hindbrain morphogenesis (ortholog); in utero embryonic development (ortholog); midbrain development (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288056991 | hes3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286385823 | hes3.S | | | | | | African Clawed Frog | | symbol | gene, null |