| 1308191 | Guca1b | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium sensitive guanylate cyclase activator activity (ortholog); guanylate cyclase regulator activity (ortholog); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediat ed signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment; photoreceptor outer segment; cilium (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; furan | 9 | 21097274 | 21105107 | Rat | 87 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317826 | GUCA1B | guanylate cyclase activator 1B | The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmen tosa. [provided by RefSeq, Nov 2009] | 6 | 42183284 | 42194956 | Human | 205 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317827 | Guca1b | guanylate cyclase activator 1B | Enables calcium sensitive guanylate cyclase activator activity. Acts upstream of or within phototransduction; regulation of guanylate cyclase activity; and visual perception. Located in photoreceptor outer segment. Is expressed in retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 48. Orthologous to human GUCA1B (guanylate cyclase activator 1B). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 47692526 | 47703892 | Mouse | 101 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8934912 | Guca1b | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium sensitive guanylate cyclase activator activity (ortholog); guanylate cyclase regulator activity (ortholog); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediat ed signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN cilium (ortholog); cone photoreceptor outer segment (ortholog); photoreceptor inner segment (ortholog) | NW_004955437 | 8384692 | 8390946 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11905206 | GUCA1B | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | 6 | 41771537 | 41783364 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12295554 | GUCA1B | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | 12 | 10796961 | 10806796 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12533424 | Guca1b | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | NW_004936476 | 17679505 | 17688970 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14216582 | GUCA1B | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18678634 | GUCA1B | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905148 | Guca1b | guanylate cyclase activator 1B | ENCODES a protein that exhibits guanylate cyclase regulator activity (ortholog); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN cilium (ortholog); photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258258 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933463 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933724 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933736 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933774 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933986 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934563 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934718 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935001 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935067 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935518 | guca1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625897434 | Guca1b | guanylate cyclase activator 1B | ENCODES a protein that exhibits calcium sensitive guanylate cyclase activator activity (ortholog); guanylate cyclase regulator activity (ortholog); INVOLVED IN phototransduction (ortholog); visual perception (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediat ed signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); retinitis pigmentosa (ortholog); FOUND IN cilium (ortholog); cone photoreceptor outer segment (ortholog); photoreceptor inner segment (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243731 | guca1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933737 | guca1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934562 | guca1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934761 | guca1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936176 | guca1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083479 | guca1bl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858394 | guca1bl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859686 | guca1bl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626178887 | guca1bl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083478 | guca1bl.S | | | | | | African Clawed Frog | | symbol | gene, null |