| 69227 | Gpx5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); PARTICIPATES IN arachidonic acid metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol; ammonium chloride | 17 | 48131853 | 48138801 | Rat | 74 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735451 | Gpx5 | glutathione peroxidase 5 | Predicted to enable glutathione peroxidase activity. Acts upstream of or within cellular response to oxidative stress. Located in extracellular space and sperm plasma membrane. Is expressed in several structures, including male reproductive gland or organ and placenta. Orthologous to human GPX5 le='font-weight:700;'>GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 21470599 | 21476897 | Mouse | 75 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1352844 | GPX5 | glutathione peroxidase 5 | This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine resid ue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016] | 6 | 28525881 | 28534955 | Human | 77 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11981148 | GPX5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | 6 | 28340291 | 28348504 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12146109 | GPX5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | 35 | 25653627 | 25662490 | Dog | 14 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12540205 | Gpx5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | NW_004936914 | 487163 | 496465 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18719610 | GPX5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14293205 | GPX5 | glutathione peroxidase 5 | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | | | | Pig | 14 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626150886 | Gpx5 | glutathione peroxidase 5 | INVOLVED IN cellular response to oxidative stress (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); sperm plasma membrane (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912736 | LOC101698603 | epididymal secretory glutathione peroxidase | ENCODES a protein that exhibits glutathione peroxidase activity (inferred); oxidoreductase activity (inferred); peroxidase activity (inferred); INVOLVED IN cellular oxidant detoxification (inferred); response to oxidative stress (inferred); FOUND IN extracellular region (inferred) | | | | Naked Mole-Rat | 9 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8724624 | LOC102008516 | epididymal secretory glutathione peroxidase | | NW_004955465 | 13787944 | 13795076 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 735998 | GPX6 | glutathione peroxidase 6 | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017] | 6 | 28503296 | 28515793 | Human | 69 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |