| 61963 | Fhl2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); identical protein binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of calcineurin-NFAT signaling cascade; atrial cardiac muscle cell development (ortholog); heart trabecula formation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Cardiomegaly (ortholog); FOUND IN M band; Z disc; actin cytoskeleton (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 52881091 | 52954540 | Rat | 299 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62256 | Fhl2 | four and a half LIM domains 2 | This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated m uscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] | 1 | 43162233 | 43237501 | Mouse | 302 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1350947 | FHL2 | four and a half LIM domains 2 | This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extra cellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016] | 2 | 105357712 | 105438529 | Human | 344 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8939963 | Fhl2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); identical protein binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN atrial cardiac muscle cell development (ortholog); heart trabecula formation (ortholog); negative regulation of apoptotic pro cess (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Cardiomegaly (ortholog); FOUND IN actin cytoskeleton (ortholog); focal adhesion (ortholog); M band (ortholog) | NW_004955470 | 10240117 | 10286117 | Chinchilla | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11879456 | FHL2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); C ardiomegaly (ortholog); FOUND IN M band (ortholog); Z disc (ortholog) | 2A | 96391513 | 96469267 | Bonobo | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12075734 | FHL2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); C ardiomegaly (ortholog); FOUND IN M band (ortholog); Z disc (ortholog) | 10 | 37997912 | 38065633 | Dog | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12715060 | Fhl2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); C ardiomegaly (ortholog); FOUND IN M band (ortholog); Z disc (ortholog) | NW_004936764 | 613863 | 656220 | Squirrel | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14275432 | FHL2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN atrial cardiac muscle cell development (ortholog); heart trabecula formation (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Cardiomegaly (ortholog); FOUND IN actin cytoskeleton (ortholog); focal adhesion (ortholog); M band (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917242 | Fhl2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); C ardiomegaly (ortholog); FOUND IN M band (ortholog); Z disc (ortholog) | | | | Naked Mole-Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18628181 | FHL2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); C ardiomegaly (ortholog); FOUND IN M band (ortholog); Z disc (ortholog) | | | | Green Monkey | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241114 | fhl2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626161696 | Fhl2 | four and a half LIM domains 2 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); identical protein binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN atrial cardiac muscle cell development (ortholog); heart trabecula formation (ortholog); negative regulation of apoptotic pro cess (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Cardiomegaly (ortholog); FOUND IN actin cytoskeleton (ortholog); focal adhesion (ortholog); M band (ortholog) | | | | Black Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238394 | fhl2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241113 | fhl2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16557122 | AC108058.1 | novel transcript, antisense to FHL2 | | | | | Human | | name | gene, lncrna |
| 626056975 | C13H10orf71 | chromosome 13 C10orf71 homolog | INVOLVED IN positive regulation of calcineurin-NFAT signaling cascade (ortholog); ASSOCIATED WITH dilated cardiomyopathy (ortholog); FOUND IN Z disc (ortholog) | | | | Black Rat | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1350272 | PRF1 | perforin 1 | This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or i n an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017] | 10 | 70597348 | 70602741 | Human | 686 | description | gene, protein-coding, REVIEWED [RefSeq] |