| 1310168 | Fermt3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits integrin binding (ortholog); lipid binding (ortholog); INVOLVED IN integrin activation (ortholog); integrin-mediated signaling pathway (ortholog); leukocyte cell-cell adhesion (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH ovarian can cer; acute myeloid leukemia (ortholog); blood platelet disease (ortholog); FOUND IN podosome (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 213618691 | 213636889 | Rat | 133 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320913 | Fermt3 | fermitin family member 3 | Enables integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Located in podosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinar y system; immune system; and skin. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6976326 | 6996837 | Mouse | 163 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602673 | FERMT3 | FERM domain containing kindlin 3 | Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. T his protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010] | 11 | 64205920 | 64223891 | Human | 225 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8928766 | Fermt3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits integrin binding (ortholog); lipid binding (ortholog); INVOLVED IN integrin activation (ortholog); integrin-mediated signaling pathway (ortholog); leukocyte cell-cell adhesion (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myelo id leukemia (ortholog); blood platelet disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN podosome (ortholog) | NW_004955422 | 20854297 | 20870463 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11877543 | FERMT3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN cell adhesion (inferred); cell-matrix adhesion (inferred); integrin activation (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); blood platelet disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN anchoring junction (inferred); cell projection (inferred); cell-substrate junction (inferred) | 11 | 59562861 | 59581054 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311827 | FERMT3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN cell adhesion (inferred); integrin activation (inferred); integrin-mediated signaling pathway (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH leukocyte adhesion deficiency 3; acute myeloid leukemia (ortholog); blood platelet disease (ortholog); FOUND IN anchoring junction (inferred); cell projection (inferred); podosome (inferred) | 18 | 52833954 | 52851775 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12641792 | Fermt3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN cell adhesion (inferred); cell-matrix adhesion (inferred); integrin activation (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); blood platelet disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN anchoring junction (inferred); cell projection (inferred); cell-substrate junction (inferred) | NW_004936599 | 4975435 | 4989225 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14121418 | FERMT3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN cell adhesion (inferred); integrin activation (inferred); integrin-mediated signaling pathway (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); blood platelet disea se (ortholog); Desbuquois dysplasia (ortholog); FOUND IN anchoring junction (inferred); cell projection (inferred); podosome (inferred) | | | | Pig | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902837 | Fermt3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN positive regulation of cell migration (ortholog); substrate adhesion-dependent cell spreading (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); blood platelet disea se (ortholog); Desbuquois dysplasia (ortholog); FOUND IN podosome (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625894031 | Fermt3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits integrin binding (ortholog); lipid binding (ortholog); INVOLVED IN integrin activation (ortholog); integrin-mediated signaling pathway (ortholog); leukocyte cell-cell adhesion (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myelo id leukemia (ortholog); blood platelet disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN podosome (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18545791 | FERMT3 | FERM domain containing kindlin 3 | ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN cell adhesion (inferred); cell-matrix adhesion (inferred); integrin activation (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); blood platelet disease (ortholog); Desbuquois dysplasia (ortholog); FOUND IN anchoring junction (inferred); cell projection (inferred); cell-substrate junction (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259277 | fermt3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155231069 | fermt3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16564286 | AC138761.2 | fermitin family member 3 (FERMT3) pseudogene | | 17 | 22277874 | 22279406 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16563730 | AC233702.2 | fermitin family member 3 (FERMT3) pseudogene | | 17 | 21592678 | 21594210 | Human | | name | gene, pseudo, INFERRED [RefSeq] |