| 1584688 | Erfe | erythroferrone | ENCODES a protein that exhibits hormone activity (ortholog); identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN negative regulation of apoptotic process; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; intracellula r iron ion homeostasis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan | 9 | 99404512 | 99412383 | Rat | 89 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1606147 | ERFE | erythroferrone | Enables molecular sequestering activity. Involved in negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 238158970 | 238168890 | Human | 78 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614932 | Erfe | erythroferrone | Enables hormone activity and identical protein binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of osteoblast differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Located in extracellular space. Orthologous to human ERFE (erythroferrone). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 91293033 | 91301939 | Mouse | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8917558 | Erfe | erythroferrone | ENCODES a protein that exhibits hormone activity (ortholog); identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN intracellular iron ion homeostasis (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of autophagy (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | NW_004955542 | 2408504 | 2415522 | Chinchilla | 18 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13977396 | ERFE | erythroferrone | ENCODES a protein that exhibits hormone activity (inferred); identical protein binding (inferred); molecular sequestering activity (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of fatty acid transport (ortholog); regulation of fatty acid me tabolic process (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 25 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18504904 | ERFE | erythroferrone | ENCODES a protein that exhibits hormone activity (inferred); identical protein binding (inferred); molecular sequestering activity (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of fatty acid transport (ortholog); regulation of fatty acid me tabolic process (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 25 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |