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16 records found for search term Eme1
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
1309067Eme1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN double-strand break repair (ortholog); replication fork processing (ortholog); resolution of mitotic recombination intermediates (ortholog); PARTICIPATES IN homologous recombi108008358580092450Rat103symbol , old_gene_name , PhenoGengene, protein-coding, VALIDATED [RefSeq]
1319200EME1essential meiotic structure-specific endonuclease 1This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This 175037322950381483Human103symbol , old_gene_name , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1618849Eme1essential meiotic structure-specific endonuclease 1Predicted to enable DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to act upstream of or within response to intra-S DNA damage checkpoint s119453579894544611Mouse116symbol , old_gene_name , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
9044543Eme1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN double-strand break repair (ortholog); replication fork processing (ortholog); resolution of mitotic recombination intermediates (ortholog); FOUND IN chromatin (ortholog); endNW_0049554511132875911336099Chinchilla18symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
11842405EME1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN replication fork processing (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); telomere maintenance (ortholog); FOUND IN174446753744475883Bonobo33symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12325569EME1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN replication fork processing (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); telomere maintenance (ortholog); FOUND IN92634241926350561Dog30symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12666042Eme1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN replication fork processing (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); telomere maintenance (ortholog); FOUND INNW_0049364901130773911316203Squirrel30symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
13930082EME1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); endonuclease activity (inferred); INVOLVED IN replication fork processing (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); telomere maintenance (ortholog); FOUNPig30symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
625918604Eme1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN double-strand break repair (ortholog); replication fork processing (ortholog); resolution of mitotic recombination intermediates (ortholog); FOUND IN chromatin (ortholog); endBlack Rat18symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
18919843Eme1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (ortholog); INVOLVED IN replication fork processing (ortholog); resolution of mitotic recombination intermediates (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); FOUND IN chromatin (ortholog); enNaked Mole-Rat30symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
18497931EME1essential meiotic structure-specific endonuclease 1ENCODES a protein that exhibits crossover junction DNA endonuclease activity (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN replication fork processing (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); telomere maintenance (ortholog); FOUND INGreen Monkey33symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
329330023eme1Tropical Clawed Frogsymbolgene, null
286996748eme1.LAfrican Clawed Frogsymbolgene, null
1344240EME2essential meiotic structure-specific endonuclease subunit 2EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]1617728101781702Human73old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1312517ERCC4ERCC excision repair 4, endonuclease catalytic subunitThe protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xero161392015413952348Human599descriptiongene, protein-coding, REVIEWED [RefSeq]
1323679MUS81MUS81 structure-specific endonuclease subunitThis gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded pro116585967465867653Human125descriptiongene, protein-coding, REVIEWED [RefSeq]