| 1311815 | Ddi2 | DDI proteasomal shuttling factor 2 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); identical protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN cellular response to hydroxyurea (ortholog); proteasomal protein catabolic process (ortholog); protein processing (ortholog); FOUND IN cyto sol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; metformin | 5 | 159272625 | 159318365 | Rat | 86 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323467 | Ddi2 | DNA-damage inducible protein 2 | Predicted to enable aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Predicted to be located in cytosol an d nucleoplasm. Is expressed in brain. Orthologous to human DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 141410874 | 141450730 | Mouse | 116 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1603951 | DDI2 | DDI proteasomal shuttling factor 2 | Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Geno me Resources, Jul 2025] | 1 | 15617458 | 15669044 | Human | 94 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8943657 | Ddi2 | DDI proteasomal shuttling factor 2 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); identical protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN cellular response to hydroxyurea (ortholog); proteasomal protein catabolic process (ortholog); protein processing (ortholog); FOUND IN cyto sol (ortholog); nucleoplasm (ortholog) | NW_004955527 | 2498211 | 2534768 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11681754 | DDI2 | DDI proteasomal shuttling factor 2 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN cellular response to hydroxyurea (inferred); negative regulation of D-glucose transmembrane transport (inferred); proteasomal protein cata bolic process (inferred); FOUND IN cytosol (inferred); Golgi apparatus (inferred); nuclear body (inferred) | 1 | 14757327 | 14810959 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12193342 | DDI2 | DNA damage inducible 1 homolog 2 | ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); protein processing (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | 2 | 81915613 | 81957803 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233366 | ddi2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625860963 | Ddi2 | DDI proteasomal shuttling factor 2 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); identical protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN cellular response to hydroxyurea (ortholog); proteasomal protein catabolic process (ortholog); protein processing (ortholog); FOUND IN cyto sol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18627376 | DDI2 | DDI proteasomal shuttling factor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); protein processing (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232610 | ddi2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233367 | ddi2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18905303 | LOC101704457 | protein DDI1 homolog 2 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN cellular response to hydroxyurea (inferred); protein transport (inferred); proteolysis (inferred) | | | | Naked Mole-Rat | 11 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12550334 | Rsc1a1 | regulator of solute carriers 1 | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of Golgi to plasma membrane protein transport (ortholog); negative regulation of nucleoside transport (ortholog); nega tive regulation of transport (ortholog); FOUND IN cytosol (inferred); Golgi apparatus (inferred); nuclear body (inferred) | NW_004936474 | 3284512 | 3312366 | Squirrel | 25 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |