| 1309666 | Crtc3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); transcription coactivator activity (inferred); INVOLVED IN energy homeostasis (ortholog); macrophage activation (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling path way (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol | 1 | 143962038 | 144064324 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, INFERRED [RefSeq] |
| 1604314 | CRTC3 | CREB regulated transcription coactivator 3 | This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] | 15 | 90529923 | 90645345 | Human | 105 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622286 | Crtc3 | CREB regulated transcription coactivator 3 | Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in positive regulation of CREB transcription factor activity. Acts upstream of or within energy homeostasis; negative regulation of adenylate cyclase-activating adrenergic rece ptor signaling pathway; and regulation of primary metabolic process. Located in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 80236375 | 80339443 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8703124 | Crtc3 | CREB regulated transcription coactivator 3 | INVOLVED IN energy homeostasis (ortholog); macrophage activation (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955416 | 14672291 | 14768879 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11807887 | CRTC3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); transcription coactivator activity (inferred); INVOLVED IN energy homeostasis (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); negative regulatio n of lipid catabolic process (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 15 | 69217679 | 69333897 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12211836 | CRTC3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); INVOLVED IN energy homeostasis (ortholog); macrophage activation (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | 3 | 53564244 | 53669778 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12478060 | Crtc3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); transcription coactivator activity (inferred); INVOLVED IN energy homeostasis (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); negative regulatio n of lipid catabolic process (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936483 | 16356663 | 16465128 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13959958 | CRTC3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); transcription coactivator activity (inferred); INVOLVED IN energy homeostasis (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); negative regulatio n of lipid catabolic process (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18584267 | CRTC3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); transcription coactivator activity (inferred); INVOLVED IN energy homeostasis (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); negative regulatio n of lipid catabolic process (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626044905 | Crtc3 | CREB regulated transcription coactivator 3 | INVOLVED IN energy homeostasis (ortholog); macrophage activation (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248059 | crtc3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18923625 | Crtc3 | CREB regulated transcription coactivator 3 | ENCODES a protein that exhibits cAMP response element binding protein binding (inferred); INVOLVED IN energy homeostasis (ortholog); macrophage activation (ortholog); negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243181 | crtc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 9681643 | CRTC3-AS1 | CRTC3 antisense RNA 1 | ASSOCIATED WITH prostate cancer; INTERACTS WITH Aflatoxin B2 alpha; benzo[e]pyrene; lipopolysaccharide | 15 | 90620009 | 90717140 | Human | 7 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16562082 | AC103739.1 | novel transcript, antisense to CRTC3 | | | | | Human | | name | gene, lncrna |
| 16562137 | AC103739.2 | novel transcript, antisense to CRTC3 | | | | | Human | | name | gene, lncrna |
| 16570765 | AC103739.3 | novel transcript, antisense to CRTC3 | | | | | Human | | name | gene, lncrna |
| 1313593 | MAML2 | mastermind like transcriptional coactivator 2 | The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015] | 11 | 95976598 | 96343195 | Human | 108 | description | gene, protein-coding, REVIEWED [RefSeq] |
