| 1310857 | Coq5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (ortholog); INVOLVED IN methylation (ortholog); ubiquinone biosynthetic process (ortholog); PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; finasteride | 12 | 46977632 | 46994575 | Rat | 105 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322001 | Coq5 | coenzyme Q5 methyltransferase | Predicted to enable 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in heart and heart right ventricle. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 115417752 | 115435029 | Mouse | 113 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604266 | COQ5 | coenzyme Q5, methyltransferase | Enables 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity. Involved in methylation and ubiquinone biosynthetic process. Located in mitochondrial inner membrane and mitochondrial matrix. Part of ubiquinone biosynthesis complex. Implicated in primary coenzyme Q10 deficiency 9. [provide d by Alliance of Genome Resources, Jul 2025] | 12 | 120503279 | 120529158 | Human | 127 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8714554 | Coq5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (ortholog); INVOLVED IN methylation (ortholog); ubiquinone biosynthetic process (ortholog); PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog) | NW_004955455 | 11124009 | 11142665 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11721119 | COQ5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN ketone biosynthetic process (inferred); methylation (inferred); ubiquinone biosynthetic process (inferred) ; PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog) | 12 | 118085605 | 118112591 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12108642 | COQ5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN ketone biosynthetic process (inferred); methylation (inferred); ubiquinone biosynthetic process (inferred) ; PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog) | 26 | 16404370 | 16421507 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12718242 | Coq5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN methylation (inferred); ubiquinone biosynthetic process (inferred); PARTICIPATES IN ubiquinone biosyntheti c pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog) | NW_004936668 | 431453 | 446881 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625911609 | Coq5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (ortholog); INVOLVED IN methylation (ortholog); ubiquinone biosynthetic process (ortholog); PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14371616 | COQ5 | | | | | | Yeast | | symbol | gene, null |
| 13918987 | COQ5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN ketone biosynthetic process (inferred); methylation (inferred); ubiquinone biosynthetic process (inferred) ; PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog) | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901268 | Coq5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN methylation (inferred); ubiquinone biosynthetic process (inferred); PARTICIPATES IN ubiquinone biosyntheti c pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18451031 | COQ5 | coenzyme Q5, methyltransferase | ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN methylation (inferred); ubiquinone biosynthetic process (inferred); PARTICIPATES IN ubiquinone biosyntheti c pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN mitochondrial inner membrane (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243743 | coq5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155243742 | coq5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1352777 | METTL27 | methyltransferase like 27 | This gene encodes a protein belonging to ubiE/COQ5 methyltransferase family. The gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.22-q11.23. [provided by RefSeq, Jul 2008] | 7 | 73834590 | 73842516 | Human | 246 | description | gene, protein-coding, REVIEWED [RefSeq] |