| 1307932 | Cldn4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm; female pregnancy; response to progesterone; PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH peptic esophagitis; Reperfusion Injury; Breast Neoplasms (orth olog); FOUND IN apical plasma membrane; apicolateral plasma membrane; basal plasma membrane; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene | 12 | 27388160 | 27389958 | Rat | 284 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317413 | CLDN4 | claudin 4 | The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clos tridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013] | 7 | 73830996 | 73832690 | Human | 276 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317414 | Cldn4 | claudin 4 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers. [provided by RefSeq, Aug 2010] | 5 | 134973977 | 134975788 | Mouse | 307 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8708046 | Cldn4 | claudin 4 | INVOLVED IN circadian rhythm (ortholog); establishment of skin barrier (ortholog); female pregnancy (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); malignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membra ne (ortholog); basal plasma membrane (ortholog) | NW_004955456 | 13961743 | 13965498 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12377761 | CLDN4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); establishment of skin barrier (ortholog); female pregnancy (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortho log); malignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog); INTERACTS WITH all-trans-retinoic acid; anthra[1,9-cd]pyrazol-6(2H)-one; D-mannitol | 6 | 6492706 | 6506750 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12720504 | Cldn4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); female pregnancy (ortholog); paracellular transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); m alignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog) | NW_004936543 | 2984797 | 2986563 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243268 | cldn4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 11867897 | CLDN4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); female pregnancy (ortholog); paracellular transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); m alignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog) | | | | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13853488 | CLDN4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); female pregnancy (ortholog); response to progesterone (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); malignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog); INTERACTS WITH 3-acetyldeoxynivalenol; amino acid; deoxynivalenol | | | | Pig | 62 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18904165 | Cldn4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); establishment of skin barrier (ortholog); female pregnancy (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortho log); malignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 150657575 | CLDN4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN chloride transmembrane transport (inferred); chloride transport (inferred); monoatomic ion transmembrane transport (inferred); FOUND IN bicellular tight junction (inferred); chl oride channel complex (inferred); membrane (inferred) | | | | Dog | 15 | symbol | gene, protein-coding |
| 18474262 | CLDN4 | claudin 4 | ENCODES a protein that exhibits chloride channel activity (inferred); structural molecule activity (inferred); INVOLVED IN circadian rhythm (ortholog); female pregnancy (ortholog); paracellular transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); m alignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog); basal plasma membrane (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625836223 | Cldn4 | claudin 4 | INVOLVED IN circadian rhythm (ortholog); establishment of skin barrier (ortholog); female pregnancy (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); invasive ductal carcinoma (ortholog); malignant mesothelioma (ortholog); FOUND IN apical plasma membrane (ortholog); apicolateral plasma membra ne (ortholog); basal plasma membrane (ortholog) | | | | Black Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241927 | cldn4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247258 | cldn4.S | | | | | | African Clawed Frog | | symbol | gene, null |