| 1351425 | CLDN18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] | 3 | 137998816 | 138033649 | Human | 91 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359696 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN response to ethanol; cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A | 8 | 109125819 | 109145110 | Rat | 86 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552402 | Cldn18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010] | 9 | 99572849 | 99599320 | Mouse | 106 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8849903 | Cldn18 | claudin 18 | INVOLVED IN cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); epithelial cell proliferation (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog) | NW_004955501 | 962188 | 991922 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12037168 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | 3 | 135037555 | 135061105 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12260633 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | 23 | 34229115 | 34257431 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12688411 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | NW_004936540 | 373889 | 401535 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13932853 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Pig | 34 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18625946 | CLDN18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626015042 | Cldn18 | claudin 18 | INVOLVED IN cellular response to estrogen stimulus (ortholog); digestive tract development (ortholog); epithelial cell proliferation (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN cell-cell junction (ortholog); plasma membrane (ortholog); tight junction (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910727 | Cldn18 | claudin 18 | ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN digestive tract development (ortholog); negative regulation of bone resorption (ortholog); negative regulation of osteoclast development (ortholog); ASSOCIATED WITH asthma (ortholog); megacolon (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255233 | cldn18 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251411 | cldn18.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259775 | cldn18.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16566467 | AC016252.1 | novel transcript, antisense to CLDN18 | | | | | Human | | name | gene, lncrna |
