| 1317694 | CHD5 | chromodomain helicase DNA binding protein 5 | This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012] | 1 | 6101787 | 6180321 | Human | 168 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550898 | Chd5 | chromodomain helicase DNA binding protein 5 | Enables histone H3K27me3 reader activity; histone binding activity; and histone deacetylase binding activity. Involved in several processes, including cerebral cortex neuron differentiation; positive regulation of signal transduction by p53 class mediator; and sperm DNA condensation. Located in hete rochromatin and nucleus. Part of NuRD complex. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 152423103 | 152474651 | Mouse | 130 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1582725 | Chd5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding; histone binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN transcription by RNA polymerase II; cerebral cortex neuron differentiation (ortholog); chromatin remodeling (ortholog); PARTICIPATES IN CHD family mediated chromatin rem odeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN chromatin; nucleus; heterochromatin (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A | 5 | 168130851 | 168181705 | Rat | 128 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8783600 | Chd5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); chromatin remodeling (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPA TES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog); nuclear speck (ortholog) | NW_004955486 | 6320380 | 6369020 | Chinchilla | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11834365 | CHD5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN heterochromatin (ortholog) | 1 | 4867636 | 4947401 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12101919 | CHD5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog) | 5 | 60022451 | 60080663 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12504897 | Chd5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN heterochromatin (ortholog) | NW_004936623 | 988423 | 1046969 | Squirrel | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235404 | chd5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18498194 | CHD5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN heterochromatin (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626087223 | Chd5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); chromatin remodeling (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPA TES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog); nuclear speck (ortholog) | | | | Black Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13892813 | CHD5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog) | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913783 | Chd5 | chromodomain helicase DNA binding protein 5 | ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); histone H3K27me3 reader activity (ortholog); INVOLVED IN cerebral cortex neuron differentiation (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of tr anscription by RNA polymerase II (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Developmental Disabilities (ortholog); epilepsy (ortholog); FOUND IN heterochromatin (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235403 | chd5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259730 | chd5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1321381 | CHD6 | chromodomain helicase DNA binding protein 6 | This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013] | 20 | 41402083 | 41618377 | Human | 146 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352136 | GET1 | guided entry of tail-anchored proteins factor 1 | This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated diff erentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017] | 21 | 39380326 | 39428528 | Human | 98 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552109 | Get1 | guided entry of tail-anchored proteins factor 1 | Predicted to enable protein-membrane adaptor activity. Acts upstream of or within several processes, including otic vesicle development; post-translational protein targeting to endoplasmic reticulum membrane; and sensory perception of sound. Predicted to be located in endoplasmic reticulum. Predicte d to be part of GET complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 95946600 | 95959052 | Mouse | 110 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601887 | KALRN | kalirin RhoGEF kinase | Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding prote in that may function in vesicle trafficking. [provided by RefSeq, Apr 2016] | 3 | 124033369 | 124726325 | Human | 214 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14207264 | CHD6 | chromodomain helicase DNA binding protein 6 | ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent activity, acting on DNA (inferred); DNA binding (inferred); INVOLVED IN cell redox homeostasis (inferred); chromatin organization (inferred); DNA-templated transcription (inferred); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH neuroblastoma (ortholog); Prostatic Neoplasms (ortholog); transitional cell carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 29 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |