| 1308382 | Cdc42ep5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN JNK cascade (ortholog); positive regulation of actin filament polymerization (ortholog); positive regulation of pseudopodium assembly (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); plasma membrane (ortholog ); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene | 1 | 79108036 | 79110550 | Rat | 101 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1318117 | CDC42EP5 | CDC42 effector protein 5 | Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Bo rg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013] | 19 | 54465026 | 54473296 | Human | 114 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1318118 | Cdc42ep5 | CDC42 effector protein 5 | Predicted to enable small GTPase binding activity. Acts upstream of or within JNK cascade and Rho protein signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Res ources, Jul 2025] | 7 | 4154259 | 4167830 | Mouse | 123 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11973403 | CDC42EP5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN JNK cascade (ortholog); positive regulation of actin filament polymerization (ortholog); positive regulation of pseudopodium assembly (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); plasma membrane (ortholog ) | 19 | 51411848 | 51419686 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12122548 | CDC42EP5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN JNK cascade (ortholog); Rho protein signal transduction (ortholog); FOUND IN cytoplasm (inferred); endomembrane system (inferred); membrane (inferred) | 1 | 102838163 | 102842586 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12531252 | Cdc42ep5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN JNK cascade (ortholog); Rho protein signal transduction (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); membrane (inferred) | NW_004936886 | 176214 | 181007 | Squirrel | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13987522 | CDC42EP5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN JNK cascade (ortholog); Rho protein signal transduction (ortholog); FOUND IN cytoplasm (inferred); endomembrane system (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18394761 | CDC42EP5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN JNK cascade (ortholog); Rho protein signal transduction (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); endomembrane system (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927633 | Cdc42ep5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN JNK cascade (ortholog); Rho protein signal transduction (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); endomembrane system (inferred) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626072536 | Cdc42ep5 | CDC42 effector protein 5 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN JNK cascade (ortholog); positive regulation of actin filament polymerization (ortholog); positive regulation of pseudopodium assembly (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); plasma membrane (ortholog ) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |