| 1345702 | ADGRE2 | adhesion G protein-coupled receptor E2 | This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like s pacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012] | 19 | 14724171 | 14778560 | Human | 94 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1305595 | Adgre5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH 2,6-dinitrotoluene; acetamide; acrylamide | 19 | 41302687 | 41332183 | Rat | 130 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313717 | ADGRE5 | adhesion G protein-coupled receptor E5 | This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] | 19 | 14381444 | 14408723 | Human | 150 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313718 | Adgre5 | adhesion G protein-coupled receptor E5 | Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 84449874 | 84467812 | Mouse | 142 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8843904 | Adgre5 | adhesion G protein-coupled receptor E5 | INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | NW_004955415 | 33007959 | 33021896 | Chinchilla | 6 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11772049 | ADGRE5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | 19 | 13944894 | 13972041 | Bonobo | 21 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12375126 | ADGRE5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | 20 | 48204738 | 48220249 | Dog | 23 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12630368 | Adgre5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | NW_004936659 | 2955633 | 2973277 | Squirrel | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14095147 | ADGRE5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH zearalenone | | | | Pig | 28 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18936532 | Adgre5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16564605 | AC008569.1 | novel transcript, antisense to CD97 | | | | | Human | | name | gene, lncrna |
| 626125513 | Adgre5 | adhesion G protein-coupled receptor E5 | INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Black Rat | 6 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18551408 | ADGRE5 | adhesion G protein-coupled receptor E5 | ENCODES a protein that exhibits calcium ion binding (inferred); G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN positive regulation of synapse assembly (ortholog); ASSOCIATED WITH lung disease (ortholog); pancreatic cancer (ortholog); FOUND IN external side of plasma membrane (ortholog) | | | | Green Monkey | 26 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |