| 708370 | Card9 | caspase recruitment domain family, member 9 | ENCODES a protein that exhibits CARD domain binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN response to aldosterone; antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN NOD-like rece ptor signaling pathway; tuberculosis pathway; ASSOCIATED WITH retinal degeneration; RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES; ankylosing spondylitis (ortholog); FOUND IN CBM complex (ortholog); cytoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 3 | 29569907 | 29578402 | Rat | 175 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732385 | CARD9 | caspase recruitment domain family member 9 | The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008] | 9 | 136363956 | 136373669 | Human | 199 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1615540 | Card9 | caspase recruitment domain family, member 9 | Enables CARD domain binding activity. Involved in several processes, including antifungal innate immune response; positive regulation of MAPK cascade; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of JNK cascade; regulation of cytokine production; and response to bacterium. Part of CBM complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 26242199 | 26250957 | Mouse | 179 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8716606 | Card9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits CARD domain binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); defense response to Gram-positive bacterium (ortholog) ; ASSOCIATED WITH ankylosing spondylitis (ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN CBM complex (ortholog); cytoplasm (ortholog); protein-containing complex (ortholog) | NW_004955513 | 4350873 | 4359345 | Chinchilla | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11829845 | CARD9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN cytoplasm (ortholog) | 9 | 107432709 | 107446271 | Bonobo | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12362942 | CARD9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN CBM complex (inferred); cytoplasm (inferred); protein-containing complex (inferred) | 9 | 49110913 | 49120758 | Dog | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12716537 | Card9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936669 | 1428208 | 1438012 | Squirrel | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903241 | Card9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625917111 | Card9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits CARD domain binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); defense response to Gram-positive bacterium (ortholog) ; ASSOCIATED WITH ankylosing spondylitis (ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN CBM complex (ortholog); cytoplasm (ortholog); protein-containing complex (ortholog) | | | | Black Rat | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18539174 | CARD9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236370 | card9 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13961108 | CARD9 | caspase recruitment domain family member 9 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); defense response to virus (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH ankylosing spondylitis ( ortholog); genetic disease (ortholog); IgA glomerulonephritis (ortholog); FOUND IN CBM complex (inferred); cytoplasm (inferred); protein-containing complex (inferred) | | | | Pig | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236369 | card9.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231798 | card9.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1347575 | BCL10 | BCL10 immune signaling adaptor | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with oth er CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 1 | 85265776 | 85276632 | Human | 335 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351045 | CLEC6A | C-type lectin domain containing 6A | The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neo formans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] | 12 | 8455962 | 8478330 | Human | 96 | description | gene, protein-coding, REVIEWED [RefSeq] |
