| 1560748 | Bbs10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndr ome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 7 | 48637324 | 48640395 | Rat | 96 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605944 | BBS10 | Bardet-Biedl syndrome 10 | This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are str ucturally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010] | 12 | 76344474 | 76348415 | Human | 438 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622272 | Bbs10 | Bardet-Biedl syndrome 10 | Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including neuronal action potential; retina morphogenesis in camera-type eye; and visual perception. Predicted to be located in cilium. Is expressed in seve ral structures, including alimentary system; cardiovascular system; genitourinary system; pituitary gland; and respiratory system. Used to study Bardet-Biedl syndrome 10. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 10. Orthologous to human BBS10 (Bardet-Biedl syndrome 10). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 111134540 | 111137597 | Mouse | 128 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9036935 | Bbs10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndr ome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog) | NW_004955405 | 15571458 | 15574568 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11907934 | BBS10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); FOUND IN cilium (inferred) | 12 | 73862775 | 73867377 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12587033 | Bbs10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog) | NW_004936568 | 4640611 | 4644627 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14224063 | BBS10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); FOUND IN chaperonin-containing T-complex (inferred) | | | | Pig | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625933747 | Bbs10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndr ome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40920409 | BBS10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (inferred); non-motile cilium assembly (inferred); photoreceptor cell maintenance (inferred); FOUND IN chape ronin-containing T-complex (inferred) | | | | Dog | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253241 | bbs10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18928144 | Bbs10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndr ome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); FOUND IN cilium (inferred) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18644837 | BBS10 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); hydrolase activity (inferred); nucleotide binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); FOUND IN cilium (inferred) | | | | Green Monkey | 39 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155238357 | bbs10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 12055364 | LOC100688777 | Bardet-Biedl syndrome 10 | ENCODES a protein that exhibits ATP binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); cone retinal bipolar cell differentiation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 1 (ortholog); Bardet-Biedl syndrome 10 (ortholog); FOUND IN chaperonin-containing T-complex (inferred) | 15 | 19302988 | 19334763 | Dog | 35 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1319511 | BBS7 | Bardet-Biedl syndrome 7 | This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of th ree chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Oct 2014] | 4 | 121824329 | 121870474 | Human | 339 | description | gene, protein-coding, REVIEWED [RefSeq] |
