| 2146 | Aqp8 | aquaporin 8 | ENCODES a protein that exhibits ammonium channel activity; methylammonium channel activity; water channel activity; INVOLVED IN ammonium import across plasma membrane; ammonium transmembrane transport; canalicular bile acid transport; PARTICIPATES IN bile acid transport pathway; ASSOCIATED WITH brai n ischemia; FOUND IN apical plasma membrane; basolateral plasma membrane; brush border membrane; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol 17-glucosiduronic acid | 1 | 187424314 | 187430243 | Rat | 241 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737411 | AQP8 | aquaporin 8 | Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008 ] | 16 | 25216947 | 25228932 | Human | 184 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737412 | Aqp8 | aquaporin 8 | Enables ammonium channel activity; urea channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; hydrogen peroxide transmembrane transport; and urea transport. Located in several cellular components, including intracellular canali culus; mitochondrion; and smooth endoplasmic reticulum. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and submandibular gland primordium. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 123061517 | 123067226 | Mouse | 221 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8925307 | Aqp8 | aquaporin 8 | ENCODES a protein that exhibits ammonium channel activity (ortholog); methylammonium channel activity (ortholog); urea channel activity (ortholog); INVOLVED IN ammonium import across plasma membrane (ortholog); ammonium transmembrane transport (ortholog); B cell differentiation (ortholog); ASSOCIATE D WITH brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | NW_004955493 | 3550697 | 3558875 | Chinchilla | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12155691 | AQP8 | aquaporin 8 | ENCODES a protein that exhibits water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); transepithelial water transport (ortholog); water transport (ortholog); ASSOCIATED WITH brain ischemia (ortholog); FOUND IN brush border membrane (ortholog); intracellular canal iculus (ortholog); mitochondrial membrane (ortholog) | 6 | 20984868 | 20992647 | Dog | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12684017 | Aqp8 | aquaporin 8 | ENCODES a protein that exhibits water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); transepithelial water transport (ortholog); water transport (ortholog); ASSOCIATED WITH brain ischemia (ortholog); FOUND IN brush border membrane (ortholog); intracellular canal iculus (ortholog); mitochondrial membrane (ortholog) | NW_004936501 | 9430872 | 9438182 | Squirrel | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625943339 | Aqp8 | aquaporin 8 | ENCODES a protein that exhibits ammonium channel activity (ortholog); methylammonium channel activity (ortholog); urea channel activity (ortholog); INVOLVED IN ammonium import across plasma membrane (ortholog); ammonium transmembrane transport (ortholog); B cell differentiation (ortholog); ASSOCIATE D WITH brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11784331 | AQP8 | aquaporin 8 | ENCODES a protein that exhibits water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); transepithelial water transport (ortholog); water transport (ortholog); ASSOCIATED WITH brain ischemia (ortholog); FOUND IN brush border membrane (ortholog); intracellular canal iculus (ortholog); mitochondrial membrane (ortholog) | | | | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18695651 | AQP8 | aquaporin 8 | ENCODES a protein that exhibits water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); transepithelial water transport (ortholog); water transport (ortholog); ASSOCIATED WITH brain ischemia (ortholog); FOUND IN brush border membrane (ortholog); intracellular canal iculus (ortholog); mitochondrial membrane (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18936227 | Aqp8 | aquaporin 8 | ENCODES a protein that exhibits methylammonium channel activity (ortholog); urea channel activity (ortholog); water channel activity (ortholog); INVOLVED IN ammonium transmembrane transport (ortholog); B cell differentiation (ortholog); canalicular bile acid transport (ortholog); ASSOCIATED WITH bra in ischemia (ortholog); FOUND IN apical part of cell (ortholog); brush border membrane (ortholog); intracellular canaliculus (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14101011 | AQP8 | aquaporin 8 | ENCODES a protein that exhibits water channel activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); transepithelial water transport (ortholog); water transport (ortholog); ASSOCIATED WITH brain ischemia (ortholog); FOUND IN brush border membrane (ortholog); intracellular canal iculus (ortholog); mitochondrial membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 53 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155259244 | aqp8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155256310 | aqp8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857892 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859696 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861506 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182114 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858831 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188932 | aqp8.S | | | | | | African Clawed Frog | | symbol | gene, null |