| 1311772 | Ap1s3 | adaptor related protein complex 1 subunit sigma 3 | ENCODES a protein that exhibits clathrin adaptor activity (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog); FOUND IN AP-1 adaptor complex (inferred); clathrin-coated pit (inferred); cytoplasmic vesicle (inferred); INTERACTS WITH 2,3, 7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; aflatoxin B1 | 9 | 88399109 | 88458396 | Rat | 104 | symbol , PhenoGen | gene, protein-coding, INFERRED [RefSeq] |
| 1323403 | AP1S3 | adaptor related protein complex 1 subunit sigma 3 | This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for disp lay of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] | 2 | 223755326 | 223837582 | Human | 150 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557609 | Ap1s3 | adaptor-related protein complex AP-1, sigma 3 | Predicted to enable clathrin adaptor activity. Predicted to be involved in protein targeting and vesicle-mediated transport. Predicted to be located in early endosome; lysosomal membrane; and trans-Golgi network membrane. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intrac ellular membrane-bounded organelle. Is expressed in bladder; embryo; renal cortex; urethra; and urinary system. Human ortholog(s) of this gene implicated in psoriasis 15. Orthologous to human AP1S3 (adaptor related protein complex 1 subunit sigma 3). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 79584593 | 79649736 | Mouse | 113 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8791405 | Ap1s3 | adaptor related protein complex 1 subunit sigma 3 | INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog) | NW_004955453 | 10183640 | 10242195 | Chinchilla | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11806849 | AP1S3 | adaptor related protein complex 1 subunit sigma 3 | ENCODES a protein that exhibits clathrin adaptor activity (inferred); INVOLVED IN intracellular protein transport (inferred); protein targeting (inferred); protein transport (inferred); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog); FOUND IN AP-1 adaptor complex (inferred); clathrin- coated pit (inferred); cytoplasm (inferred) | 2B | 111000537 | 111083518 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12223822 | AP1S3 | adaptor related protein complex 1 subunit sigma 3 | INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog) | 37 | 29561566 | 29609776 | Dog | 5 | symbol | gene, protein-coding |
| 155253590 | ap1s3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18919143 | Ap1s3 | adaptor related protein complex 1 subunit sigma 3 | ENCODES a protein that exhibits clathrin adaptor activity (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog); FOUND IN AP-1 adaptor complex (inferred); clathrin-coated pit (inferred); cytoplasmic vesicle (inferred) | | | | Naked Mole-Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626127523 | Ap1s3 | adaptor related protein complex 1 subunit sigma 3 | INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog) | | | | Black Rat | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18650123 | AP1S3 | adaptor related protein complex 1 subunit sigma 3 | ENCODES a protein that exhibits clathrin adaptor activity (inferred); INVOLVED IN intracellular protein transport (inferred); protein targeting (inferred); protein transport (inferred); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog); FOUND IN AP-1 adaptor complex (inferred); clathrin- coated pit (inferred); cytoplasmic vesicle (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14022817 | AP1S3 | adaptor related protein complex 1 subunit sigma 3 | ENCODES a protein that exhibits clathrin adaptor activity (inferred); INVOLVED IN intracellular protein transport (inferred); protein targeting (inferred); protein transport (inferred); ASSOCIATED WITH psoriasis (ortholog); psoriasis 15 (ortholog); FOUND IN AP-1 adaptor complex (inferred); clathrin- coated pit (inferred); cytoplasmic vesicle (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856476 | ap1s3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856792 | ap1s3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860726 | ap1s3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857749 | ap1s3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180865 | ap1s3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256227 | ap1s3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12652319 | LOC101955400 | AP-1 complex subunit sigma-3 | ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); clathrin adaptor activity (inferred); metal ion binding (inferred); INVOLVED IN intracellular protein transport (inferred); positive regulation of toll-like receptor 3 signaling pathway (inferred); positive regulation of toll -like receptor 4 signaling pathway (inferred); FOUND IN AP-1 adaptor complex (inferred); clathrin-coated pit (inferred); cytoplasmic vesicle (inferred) | NW_004936569 | 5574591 | 5604948 | Squirrel | 30 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16571362 | AC093884.1 | novel protein, WDFY1-AP1S3 readthrough | | | | | Human | | name | gene, protein-coding |
