RGD:62887411 Rat Genome Database

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Variant: RGD:62887411 -  Rattus norvegicus

RGD ID: 62887411
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: Tjp2  
Reference Nucleotide: G
Variant Nucleotide: A
Position
Assembly Chr Position
Rnor_5.0 1 249,259,063
JBrowse: View Region in Genome Browser (JBrowse)
Model




Gene Symbol:Tjp2
Accession:NM_053773
Location:EXON
Amino Acid Prediction: R to W (nonsynonymous)
Amino Acid Position: 262
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment   NO -2.266 -5.078 +2.812 398   NP_446225   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQ
QLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQR
AQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSP
SYDRRAHPETRYERSRSREHLWSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATK
DGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERR
QQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRPSP
EDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPK
GETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIP
NKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIA
DIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQG
IKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDR
MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRD
QLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVG
ESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMRPPEPQKAPS
RLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL*

Gene Symbol:Tjp2
Accession:XM_006231176
Location:EXON
Amino Acid Prediction: R to W (nonsynonymous)
Amino Acid Position: 353
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment     -2.278 -5.308 +3.030 570   XP_006231238   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MGLYTEKDKMRYKKYMAILEAAVGITPLNKRELLPESRRHVNLWQHPGARSPALLSSPCQWDWHPGYSSRPKHSAAHRPV
STYSLLSQGPGMEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTP
MEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSRHSSHDMLSHSWE
DSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQA
YEPDYEGRYSPSYDRRAHPETRYERSRSREHLWSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFI
KEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEVEDISEIE
SNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPR
TASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVRE
DAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVR
IGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGF
KRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPI
VIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGK
MEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEEVRNQNREDS
FNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHK
AKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQL
AAHSKRGYYSQPSRYRDTEL*

Gene Symbol:Tjp2
Accession:XM_006231177
Location:EXON
Amino Acid Prediction: R to W (nonsynonymous)
Amino Acid Position: 289
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment     -2.091 -5.204 +3.113 566   XP_006231239   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MRAAQVFQRMWIQAVKKLERWKGHGPGMEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD
GLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYS
ERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRS
IDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLWSRSPTPESRSRQEHKGQHDPDRPIGVLLTKS
KANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIP
SLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEA
NKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGD
QILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRV
VDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVS
TKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDV
TPKAVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKD
SIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSS
EPVQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPP
IAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIY
AVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL*

Gene Symbol:Tjp2
Accession:XM_006231178
Location:EXON
Amino Acid Prediction: R to W (nonsynonymous)
Amino Acid Position: 285
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment     -2.132 -5.114 +2.982 391   XP_006231240   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MPVRGDRGFPLRRELSGWQRGPGMEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQ
ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYSERSR
HSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRSIDRD
YDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLWSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANE
EYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLND
SDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEANKEP
RSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILK
VNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTL
YDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVSTKFP
AYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKA
VDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQ
QQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQ
HEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVK
PAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPI
KAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL*

Gene Symbol:Tjp2
Accession:XM_006231182
Location:EXON
Amino Acid Prediction: R to W (nonsynonymous)
Amino Acid Position: 289
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment     -2.077 -5.168 +3.091 537   XP_006231244   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MRAAQVFQRMWIQAVKKLERWKGHGPGMEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD
GLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSGYS
ERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLERGLDRDFVSRDYSRGRS
IDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHLWSRSPTPESRSRQEHKGQHDPDRPIGVLLTKS
KANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIP
SLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGATPTPFKSTGDITAAGVTEA
NKEPRSQEESPVPQPRTASRVFLRPSPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGD
QILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRV
VDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSGVKKNIRKSREDLAAAVSVS
TKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDV
TPKAVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKD
SIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSS
EPVQHEEVRNQNREDSFNYSKSNLSAMAGSEIPGGSTKGCPPPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAP
KSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHMSSRPPEPQKAPSRLYQDTRG
SYGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL*
RCS/Kyo (KyushuU)