RGD:58273286 Rat Genome Database

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Variant: RGD:58273286 -  Rattus norvegicus

RGD ID: 58273286
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: Casp8ap2  
Reference Nucleotide: G
Variant Nucleotide: C
Position
Assembly Chr Position
Rnor_5.0 5 52,480,847
JBrowse: View Region in Genome Browser (JBrowse)
Model




Gene Symbol:Casp8ap2
Accession:NM_001107921
Location:EXON
Amino Acid Prediction: D to H (nonsynonymous)
Amino Acid Position: 1711
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.456 -4.294 +2.838 135   NP_001101391   +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEY
GKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRG
RNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKET
SRERPHTRVEPQNDKNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKYH
PEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVK
SDKKSPPEHLQRTHKDTKKSTANGKRQTEQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLS
PAKKQPVCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPRTSIPENKVKEEN
RLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDI
NSCDISEGGKKKVVLSPKAAAASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPSPQ
KTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSMESSCTIPLYDSSHKDEFPSNSTLS
TFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTV
HVHKDNGRTVVKLPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKHVRKNYMKFKI
KFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQ
LDYLFEKLKKILLKFCDSVKHENDSSEGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKH
QDQNKTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQHACVKSERGFEILTEQQA
SSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELKTPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNW
SLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFL
KPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDH
FIVKIRRATPSTSPGLKHGMVAEESLTPLPRTGKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQ
TQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTKDPATETKSLELM
DVTVLDIDHLEHSKPNLDQDAQITCTSLQHHAVDAFIDLTHDVSNESKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGK
VNSSLECTVEETCIDLTSESAGSFEVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKT
KRLSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIKKKGEIIVSWTRNDDREILLE
CQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEKSKCR*

Gene Symbol:Casp8ap2
Accession:XM_006237973
Location:EXON
Amino Acid Prediction: D to H (nonsynonymous)
Amino Acid Position: 1711
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.456 -4.294 +2.838 135   XP_006238035   +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEY
GKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRG
RNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKET
SRERPHTRVEPQNDKNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKYH
PEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVK
SDKKSPPEHLQRTHKDTKKSTANGKRQTEQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLS
PAKKQPVCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPRTSIPENKVKEEN
RLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDI
NSCDISEGGKKKVVLSPKAAAASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPSPQ
KTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSMESSCTIPLYDSSHKDEFPSNSTLS
TFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTV
HVHKDNGRTVVKLPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKHVRKNYMKFKI
KFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQ
LDYLFEKLKKILLKFCDSVKHENDSSEGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKH
QDQNKTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQHACVKSERGFEILTEQQA
SSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELKTPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNW
SLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFL
KPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDH
FIVKIRRATPSTSPGLKHGMVAEESLTPLPRTGKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQ
TQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTKDPATETKSLELM
DVTVLDIDHLEHSKPNLDQDAQITCTSLQHHAVDAFIDLTHDVSNESKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGK
VNSSLECTVEETCIDLTSESAGSFEVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKT
KRLSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIKKKGEIIVSWTRNDDREILLE
CQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEKSKCR*

Gene Symbol:Casp8ap2
Accession:XM_006237974
Location:EXON
Amino Acid Prediction: D to H (nonsynonymous)
Amino Acid Position: 1711
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.456 -4.294 +2.838 135   XP_006238036   +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEY
GKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRG
RNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKET
SRERPHTRVEPQNDKNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKYH
PEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVK
SDKKSPPEHLQRTHKDTKKSTANGKRQTEQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLS
PAKKQPVCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPRTSIPENKVKEEN
RLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDI
NSCDISEGGKKKVVLSPKAAAASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPSPQ
KTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSMESSCTIPLYDSSHKDEFPSNSTLS
TFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTV
HVHKDNGRTVVKLPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKHVRKNYMKFKI
KFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQ
LDYLFEKLKKILLKFCDSVKHENDSSEGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKH
QDQNKTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQHACVKSERGFEILTEQQA
SSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELKTPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNW
SLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFL
KPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDH
FIVKIRRATPSTSPGLKHGMVAEESLTPLPRTGKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQ
TQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTKDPATETKSLELM
DVTVLDIDHLEHSKPNLDQDAQITCTSLQHHAVDAFIDLTHDVSNESKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGK
VNSSLECTVEETCIDLTSESAGSFEVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKT
KRLSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIKKKGEIIVSWTRNDDREILLE
CQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEKSKCR*

Gene Symbol:Casp8ap2
Accession:XM_006237975
Location:EXON
Amino Acid Prediction: D to H (nonsynonymous)
Amino Acid Position: 1711
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.456 -4.294 +2.838 135   XP_006238037   +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDSTARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEY
GKCQQQMKDLMKRFKEIQTQNLNLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTNNVWSRSPYQVSEGNSNEDNRRG
RNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAASRLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKET
SRERPHTRVEPQNDKNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMKYYGFNKYH
PEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQWENTPFKAERHRTEDRRKRERENKEESRHVK
SDKKSPPEHLQRTHKDTKKSTANGKRQTEQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLS
PAKKQPVCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSATSQPRTSIPENKVKEEN
RLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEVEETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDI
NSCDISEGGKKKVVLSPKAAAASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPSPQ
KTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSMESSCTIPLYDSSHKDEFPSNSTLS
TFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVDELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTV
HVHKDNGRTVVKLPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKHVRKNYMKFKI
KFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESNLKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQ
LDYLFEKLKKILLKFCDSVKHENDSSEGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKH
QDQNKTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQHACVKSERGFEILTEQQA
SSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELKTPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNW
SLLSSEKGPSLSSGLSLPVHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGHLSFL
KPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTSRSVASGFQYHPNLPMHAVIMEKSNDH
FIVKIRRATPSTSPGLKHGMVAEESLTPLPRTGKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQ
TQVPDIYEFLKDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTKDPATETKSLELM
DVTVLDIDHLEHSKPNLDQDAQITCTSLQHHAVDAFIDLTHDVSNESKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGK
VNSSLECTVEETCIDLTSESAGSFEVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKT
KRLSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIKKKGEIIVSWTRNDDREILLE
CQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEKSKCR*
NIG-III/Hok (KyushuU)