rs2046045 Rat Genome Database

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Variant: rs2046045 -  Homo sapiens

RGD ID: 406308954
RS ID: rs2046045
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: PDE8B  
Reference Nucleotide: T
Variant Nucleotide: T
Position
Assembly Chr Position
GRCh38 5 77,239,986
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
None Available GCST008165 Thyroid stimulating hormone levels 2,287 European ancestry whole-genome sequenced individuals, 14,048 European ancestry individuals G 0.414 4E-33 32.398 rs2046045 0.142 thyroid stimulating hormone measurement (EFO:0004748)
 PMID:25743335
None Available GCST006897 Hyperthyroidism 1,840 European ancestry cases, 49,983 European ancestry controls T 0.6 4E-22 21.398 rs2046045 0.329 hyperthyroidism (EFO:0009189)
 PMID:30367059
None Available GCST001487 Thyroid function 3,736 European ancestry individuals T 0.618 3E-27 26.523 rs2046045 0.115 thyroid function (EFO:0004296)
 PMID:22494929
None Available GCST90435200 Overt hyperthyroidism in pregnancy 1,648 Chinese ancestry cases, 68,140 Chinese ancestry controls T 0.160327 3E-8 7.523 rs2046045 1.41 hyperthyroidism (EFO:0009189)
 PMID:39266554
None Available GCST90296333 Thyroid stimulating hormone levels 247,107 European ancestry individuals T 0.6076 7E-781 780.155 rs2046045 0.1539 thyroid stimulating hormone measurement (EFO:0004748)
 PMID:37872160

Variant Details
Variant Transcripts
Gene Symbol:PDE8B
Accession:NM_001349753
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_001376067
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_001376075
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_001376068
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_001414622
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_001414623
Location:5UTRS;INTRON

Gene Symbol:PDE8B
Accession:NM_003719
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001029852
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001029854
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001029851
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001029853
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001349750
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001349752
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001349749
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001349748
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001349751
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376069
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376062
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376072
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376070
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376073
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376071
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376066
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376074
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376063
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376064
Location:INTRON

Gene Symbol:PDE8B
Accession:NM_001376065
Location:INTRON

Variant Samples

Additional Information

Database Acc Id Source(s)
GWAS Catalog GCST001487 GWAS Catalog
  GCST006897 GWAS Catalog
  GCST90296333 GWAS Catalog