rs3321917725 Rat Genome Database

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Variant: rs3321917725 -  Rattus norvegicus

RGD ID: 138842363
RS ID: rs3321917725
Associated ss Id(s): ss11816030057
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: Brca1  
Reference Nucleotide: C
Variant Nucleotide: G
Position
Assembly Chr Position
mRatBN7.2 10 86,449,538
JBrowse: View Region in Genome Browser (JBrowse)
Model




Gene Symbol:Brca1
Accession:XM_008768092
Location:EXON
Amino Acid Prediction: E to Q (nonsynonymous)
Amino Acid Position: 818
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.303 -3.444 +2.141 225   XP_008766314   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSQCFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEF
EVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAW
TEDNDCPDIGQLCKGRLVMWDWVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSND*

Gene Symbol:Brca1
Accession:XM_039086541
Location:EXON
Amino Acid Prediction: E to Q (nonsynonymous)
Amino Acid Position: 818
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSQCFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEF
EVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAW
TEDNDCPDIGQLCKGRLVMWDWVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSND*

Gene Symbol:Brca1
Accession:XM_039086542
Location:EXON
Amino Acid Prediction: E to Q (nonsynonymous)
Amino Acid Position: 818
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSQCFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVPRS
LISALRRKQNQKDF*

Gene Symbol:Brca1
Accession:NM_012514
Location:EXON
Amino Acid Prediction: E to Q (nonsynonymous)
Amino Acid Position: 818
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSQCFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEF
EVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAW
TEDNDCPDIGQLCKGRLVMWDWVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSND*
ACI/EurMcwi (2019) ACI/N (2020) BUF/N (2020) M520/NRrrcMcwi (2019) M520/N (2020) ACI/EurMcwi (2019NG)
M520/NRrrcMcwi (2019NG)