RGD:135121311 Rat Genome Database

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Variant: RGD:135121311 -  Rattus norvegicus

RGD ID: 135121311
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: Brca1  
Reference Nucleotide: A
Variant Nucleotide: G
Position
Assembly Chr Position
Rnor_6.0 10 89,426,178
JBrowse: View Region in Genome Browser (JBrowse)
Model




Gene Symbol:Brca1
Accession:XM_008768092
Location:EXON
Amino Acid Prediction: V to A (nonsynonymous)
Amino Acid Position: 1063
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
possibly damaging alignment   NO -1.670 -2.056 +0.386 136   XP_008766314   -
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSECFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGASKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEF
EVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAW
TEDNDCPDIGQLCKGRLVMWDWVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSND*

Gene Symbol:Brca1
Accession:NM_012514
Location:EXON
Amino Acid Prediction: V to A (nonsynonymous)
Amino Acid Position: 1063
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFS
QLVEELLKIIDAFELDTGMQCANGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLNSAKKAACDFSEGIRNIEHHQCS
DKDLNPTENHATERHPEKCPRISVANVHVEPCGTDARASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWA
DSKETCNGRPVPRTEGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLTSDNASDRR
PASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPVENIINDKIFGKTYQRKGSRPHLNHVTEIIG
TFTTEPQIIQEQPFTNKLKRKRSTCLHPEDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRG
RNAHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNPSPPTCAELQIESCGSS
EETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRKRSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPER
KGIEQLEMCQMPDNNKELGDLVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFVAS
ENPKELVHGSNNAGSGSECFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSV
PSREPSPKVTSRGEQKERQGQEESEISHVQAVTVTVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGI
SQNSHFRQSVSPLRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIEVHSTGENVQG
QLDRNRGPTVNTVSLLDSTQPGASKQSAPVSDKYLEIKQESKAVSADFSPCLFSDHLEKPMRSDKIFQVCSETPDDLLDD
VEIQENASFGEGGITEKSAIFNGSVLRRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSST
PELTRCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQHSAALGSPANALSQDPDFN
PPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQEEDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDN
LIKLQQEMAQLEAVLEQHGSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQPQPPD
GLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEKSCEPHNLTGRSCLPRQDLEGTPYLES
GISLFSSRDPDSESPKVPALVCTAPASTSALKISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVV
SGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLLSVHEF
EVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELERMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAW
TEDNDCPDIGQLCKGRLVMWDWVLDSISVYRCRDLDAYLVQNITCGRDGSEPQDSND*
WAG/RijCrl (2020)