Strain Report - Rat Genome Database

Strain Report - Rat Genome Database

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Strain Registration

General

Strain: MR/Pit
Symbol:	MR/Pit
Strain:	MR
Substrain:	Pit
RGD ID:	10029
Citation ID:	RRID:RGD_10029
Ontology ID:	RS:0000590
Type:	inbred
Available Source:	Not Available
Description:	As for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982).
Genetic Markers:	a,c,h.
Coat Color:	Albino
Inbred Generations:	F86(Pit).
Last Known Status:	Unknown

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References

References - curated

#	Reference Title	Reference Citation
1.	Inbred Strains	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2.	Update to previous Strain Data	Festing, MFW, Personal Communication Update, Feb-2000
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_behavior	Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992).	1004
strain_behavior	Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992).	634612
strain_reproduction	Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR.	1004
strain_reproduction	Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR.	634612