RGD Reference Report - Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor. - Rat Genome Database

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Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor.

Authors: Jang, SY  Shin, YK  Jung, J  Lee, SH  Seo, SY  Suh, DJ  Park, HT 
Citation: Jang SY, etal., Neurosci Lett. 2010 Nov 12;485(1):37-42. doi: 10.1016/j.neulet.2010.08.058. Epub 2010 Aug 26.
RGD ID: 8554592
Pubmed: PMID:20800647   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2010.08.058   (Journal Full-text)

Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Dpysl3Ratcellular response to cytokine stimulus involved_inIEP PMID:20800647UniProt 
Dpysl3Ratresponse to axon injury involved_inIEP PMID:20800647UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Dpysl3  (dihydropyrimidinase-like 3)


Additional Information