RGD Reference Report - Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

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Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.
Authors:	Felli, MP Maroder, M Mitsiadis, TA Campese, AF Bellavia, D Vacca, A Mann, RS Frati, L Lendahl, U Gulino, A Screpanti, I
Citation:	Felli MP, etal., Int Immunol. 1999 Jul;11(7):1017-25.
RGD ID:	8553281
Pubmed:	PMID:10383933 (View Abstract at PubMed)
The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the different members of the Notch family influence distinct steps in T cell development and the role played by Notch ligands in the thymus. We report here that different Notch receptor-ligand partnerships may occur inside the thymus, as we observed differential expression of Notch1, 2 and 3 receptors, their ligands Jagged1 and 2, and downstream intracellular effectors hairy and Enhancer of Split homolog 1 (HES-1) and hairy and Enhancer of Split homolog 5 (HES-5), depending on ontogenetic stage and thymic cell populations. Indeed, while Jagged2 is expressed in both stromal cells and thymocytes, Jagged1 expression is restricted to stromal cells. Moreover, a differential distribution of Notch3, with respect to Notch1, was observed in distinct age-related thymocyte subsets. Finally, Notch3 was preferentially up-regulated in thymocytes, following the induction of their differentiation by interaction with thymic epithelial cells expressing the cognate Jagged1 and 2 ligands, suggesting that, besides Notch1, Notch3 may also be involved in distinct steps of thymocyte development. Our results suggest that the Notch signaling pathway is involved in a complex interplay of T cell developmental stages, as a consequence of the heterogeneity and specific expression of members of the Notch receptor family and their cognate ligands, in distinct thymic cell compartments.

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Biological Process

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Jag2	Rat	regulation of cell population proliferation	involved_in	ISS	UniProtKB:Q9Y219	PMID:10383933	UniProt
Jag2	Rat	T cell differentiation	involved_in	ISS	UniProtKB:Q9Y219	PMID:10383933	UniProt
Jag2	Rat	thymic T cell selection	involved_in	ISS	UniProtKB:Q9Y219	PMID:10383933	UniProt

Molecular Function

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Jag2	Rat	growth factor activity	enables	ISS	UniProtKB:Q9Y219	PMID:10383933	UniProt

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Genes (Rattus norvegicus)

Jag2 (jagged canonical Notch ligand 2)

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Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.