RGD Reference Report - Cloning of a serotonin transporter affected by antidepressants. - Rat Genome Database

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Cloning of a serotonin transporter affected by antidepressants.

Authors: Hoffman, BJ  Mezey, E  Brownstein, MJ 
Citation: Hoffman BJ, etal., Science 1991 Oct 25;254(5031):579-80.
RGD ID: 730090
Pubmed: PMID:1948036   (View Abstract at PubMed)

A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.



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Gene Slc6a4 solute carrier family 6 member 4 Rattus norvegicus

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