RGD Reference Report - Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis. - Rat Genome Database

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Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis.

Authors: Andersen, B  Schonemann, MD  Flynn, SE  Pearse RV, 2ND  Singh, H  Rosenfeld, MG 
Citation: Andersen B, etal., Science 1993 Apr 2;260(5104):78-82.
RGD ID: 729468
Pubmed: PMID:7682011   (View Abstract at PubMed)

Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pou2f3Ratepidermis development  IDA  RGD 
Pou2f3Ratregulation of transcription by RNA polymerase II  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pou2f3  (POU class 2 homeobox 3)


Additional Information