RGD Reference Report - Retinoid chemistry: synthesis and application for metabolic disease. - Rat Genome Database

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Retinoid chemistry: synthesis and application for metabolic disease.

Authors: Curley RW, JR 
Citation: Curley RW Jr Biochim Biophys Acta. 2012 Jan;1821(1):3-9. Epub 2011 Apr 30.
RGD ID: 6904151
Pubmed: PMID:21554983   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbalip.2011.04.007   (Journal Full-text)

In this review a discussion of the usual procedures used to synthesize retinoids is followed by an overview of the structure-activity relationships of these molecules. The discussion is then focused on the role and impact of retinoids on metabolic disorders with a particular emphasis on obesity, diabetes, and the metabolic syndrome. In these areas, both natural and synthetic retinoids that are being studied are reviewed and areas where likely future research will occur are suggested. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.




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