RGD Reference Report - Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes. - Rat Genome Database

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Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes.

Authors: Zhang, R  Tan, Z  Liang, P 
Citation: Zhang R, etal., J Biol Chem 2000 Aug 11;275(32):24436-43.
RGD ID: 633078
Pubmed: PMID:10825166   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M001958200   (Journal Full-text)

The Ras signaling pathway is thought to control the expression of a subset of yet to be defined genes that are crucial for cell growth and differentiation. Here we have identified by differential display a novel oncogenic Ras target, mob-5, encoding a 23-kDa cytokine-like secreted protein. Mob-5 expression could be induced by oncogenic Ha-ras and Ki-ras, but not by normal ras activation. Inhibitors of both Ha-Ras and mitogen-activated protein kinase kinase completely abolished the mob-5 expression in ras transformed cells, with concomitant loss of the transformation phenotype. Using an alkaline phosphatase-tagged Mob-5 as ligand, a putative Mob-5 receptor was identified on the cell surface of oncogenic ras transformed cells. Thus, the Mob-5/Mob-5 receptor may represent a novel putative autocrine loop coordinately activated by ras oncogenes.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il24Ratextracellular space  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il24  (interleukin 24)


Additional Information