RGD Reference Report - A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. - Rat Genome Database

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A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes.

Authors: Otsuka, F  Shimasaki, S 
Citation: Otsuka F and Shimasaki S, Endocrinology 2002 Dec;143(12):4938-41.
RGD ID: 628419
Pubmed: PMID:12446622   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2002-220929   (Journal Full-text)

Bone morphogenetic protein-15 (BMP-15) has been known to be an oocyte-specific factor and regulate granulosa cell functions. Here, we report that BMP-15 is also expressed in the well established gonadotrope cell line, LbetaT2 and mouse pituitary tissue. Interestingly, BMP-15 stimulates FSHbeta subunit transcription in LbetaT2 cells without affecting LHbeta and GnRH receptor transcription. These findings, therefore, suggest a possible autocrine control mechanism selective for FSHbeta synthesis by BMP-15. Moreover, BMP-15 exerts a potent and selective stimulation of FSH, but not LH, secretion by primary pituitary cells. Taken together, we hypothesize that BMP-15 could play a physiological role in the monotropic rise of FSH secretion by the pituitary during the estrous and menstrual cycle. These findings, together with the previous evidence of a negative regulation of FSH receptor expression by BMP-15 in the ovary, may constitute a major role in female fertility.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bmp15Ratpositive regulation of DNA-templated transcription  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp15  (bone morphogenetic protein 15)


Additional Information