RGD Reference Report - Neutrophil C5a receptor and the outcome in a rat model of sepsis. - Rat Genome Database

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Neutrophil C5a receptor and the outcome in a rat model of sepsis.

Authors: Guo, RF  Riedemann, NC  Bernacki, KD  Sarma, VJ  Laudes, IJ  Reuben, JS  Younkin, EM  Neff, TA  Paulauskis, JD  Zetoune, FS  Ward, PA 
Citation: Guo RF, etal., FASEB J. 2003 Oct;17(13):1889-91. Epub 2003 Aug 1.
RGD ID: 5130176
Pubmed: PMID:12897064   (View Abstract at PubMed)
DOI: DOI:10.1096/fj.03-0009fje   (Journal Full-text)

Complement fragment 5a (C5a)-C5a receptor (C5aR) signaling plays an essential role in neutrophil innate immunity. Blockade of either the ligand or the receptor improves survival rates in experimental sepsis. In the current study, sepsis was induced in rats by cecal ligation/puncture. Early in sepsis C5aR content on neutrophils significantly dropped, reached the nadir at 24 h after onset of sepsis, and progressively elevated thereafter. Western-blot, RT-PCR, and confocal microscopy analyses revealed that the loss and re-expression of C5aR during sepsis might be due, at least in part, to the receptor internalization and reconstitution. The reduction and reconstitution of C5aR correlate with the loss and restoration of innate immune functions of blood neutrophils (chemotaxis and reactive oxygen species production), respectively. Quantitative measurements of C5aR on blood neutrophils are highly predictive of survival or death during sepsis. These data suggest that neutrophil C5aR content represents an essential component of an efficient defense system in sepsis and may serve as a prognostic marker for the outcome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
C5AR1HumanSepsis disease_progressionISOC5ar1 (Rattus norvegicus) RGD 
C5ar1RatSepsis disease_progressionIEP  RGD 
C5ar1MouseSepsis disease_progressionISOC5ar1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
C5ar1  (complement C5a receptor 1)

Genes (Mus musculus)
C5ar1  (complement component 5a receptor 1)

Genes (Homo sapiens)
C5AR1  (complement C5a receptor 1)


Additional Information