RGD Reference Report - Wnt/beta-catenin signaling: components, mechanisms, and diseases. - Rat Genome Database

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Wnt/beta-catenin signaling: components, mechanisms, and diseases.

Authors: MacDonald, BT  Tamai, K  He, X 
Citation: MacDonald BT, etal., Dev Cell. 2009 Jul;17(1):9-26.
RGD ID: 5130081
Pubmed: PMID:19619488   (View Abstract at PubMed)
PMCID: PMC2861485   (View Article at PubMed Central)
DOI: DOI:10.1016/j.devcel.2009.06.016   (Journal Full-text)

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.




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