RGD Reference Report - Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. - Rat Genome Database

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Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability.

Authors: Mallat, Z  Corbaz, A  Scoazec, A  Graber, P  Alouani, S  Esposito, B  Humbert, Y  Chvatchko, Y  Tedgui, A 
Citation: Mallat Z, etal., Circ Res. 2001 Sep 28;89(7):E41-5.
RGD ID: 4892618
Pubmed: PMID:11577031   (View Abstract at PubMed)

Interleukin (IL)-18 is the interferon-gamma-inducing factor and has other proinflammatory properties. The precise role of IL-18 in immunoinflammatory diseases remains poorly understood. In this study, we show that in vivo electrotransfer of an expression-plasmid DNA encoding for murine IL-18 binding protein (BP) (the endogenous inhibitor of IL-18) prevents fatty streak development in the thoracic aorta of apoE knockout mice and slows progression of advanced atherosclerotic plaques in the aortic sinus. More importantly, transfection with the IL-18BP plasmid induces profound changes in plaque composition (decrease in macrophage, T cell, cell death, and lipid content and increase in smooth muscle cell and collagen content) leading to a stable plaque phenotype. These results identify for the first time a critical role for IL-18/IL-18BP regulation in atherosclerosis and suggest a potential role for IL-18 inhibitors in reduction of plaque development/progression and promotion of plaque stability. The full text of this article is available at http://www.circresaha.org.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IL18BPHumanarteriosclerosis  ISOIl18bp (Mus musculus) RGD 
Il18bpRatarteriosclerosis  ISOIl18bp (Mus musculus) RGD 
Il18bpMousearteriosclerosis  IMP  RGD 


Genes (Rattus norvegicus)
Il18bp  (interleukin 18 binding protein)

Genes (Mus musculus)
Il18bp  (interleukin 18 binding protein)

Genes (Homo sapiens)
IL18BP  (interleukin 18 binding protein)